使用内部固体接触传感器通过直接电位法对盐酸甲烯土霉素进行定量分析。

Quantitative analysis of methacycline hydrochloride by direct potentiometry using the internal solid contact sensor.

作者信息

Sun Xian Xiang, Aboul-Enein Hassan Y

机构信息

Department of Chemical Engineering, Jiangsu Polytechnic University, Changzhou, PR China.

出版信息

Anal Sci. 2007 Feb;23(2):231-3. doi: 10.2116/analsci.23.231.

DOI:10.2116/analsci.23.231

PMID:17297239

Abstract

An internal solid contact sensor (ISCS) for the determination of methacycline hydrochloride (MC.Cl), Pt/PPy/PVC(MC-PT), is described, based on the use of conducting poly(pyrrole) (PPy) as solid contact material and MC-phosphotungstate (PT) as the ion exchanger and dibutyl phthalate (DBP) as the plasticizer. A direct potentiometric method for the quantitative analysis of MC.Cl is also described. Under the condition of pH 2.7, the linear concentration range, slope (25 degrees C) and detection limit of the sensor are 6.4 x 1.0(-6) - 3.0 x 1.0(-3) M, 52.4 +/- 0.2 mV/decade and 4.4 x 1.0(-6) M, respectively. The response time is <5 s. The determinations of MC.Cl in tablets were carried out by direct potentiometry. The average recovery and relative standard deviation are 100.1 and 0.7% (n = 4), respectively.

摘要

描述了一种用于测定盐酸甲烯土霉素（MC.Cl）的内部固体接触传感器（ISCS），即Pt/PPy/PVC（MC-PT），该传感器基于使用导电聚吡咯（PPy）作为固体接触材料，MC-磷钨酸盐（PT）作为离子交换剂，邻苯二甲酸二丁酯（DBP）作为增塑剂。还描述了一种用于MC.Cl定量分析的直接电位法。在pH 2.7的条件下，该传感器的线性浓度范围、斜率（25℃）和检测限分别为6.4×1.0⁻⁶ - 3.0×1.0⁻³ M、52.4±0.2 mV/十倍浓度变化和4.4×1.0⁻⁶ M。响应时间<5秒。通过直接电位法对片剂中的MC.Cl进行了测定。平均回收率和相对标准偏差分别为100.1%和0.7%（n = 4）。