用于药物制剂中批量和流动注射测定的西布曲明选择性电极。

Sibutramine selective electrodes for batch and flow injection determinations in pharmaceutical preparations.

作者信息

Zayed S I M, Issa Y M

机构信息

Faculty of Industrial Education, Beni Suef University, Beni Suef, Egypt.

出版信息

Anal Sci. 2010 Jan;26(1):45-9. doi: 10.2116/analsci.26.45.

DOI:10.2116/analsci.26.45

PMID:20065586

Abstract

The construction and electrochemical response characteristics of two new polyvinyl chloride (PVC) membrane sensors for the determination of sibutramine hydrochloride were described. The sensors are based on the ion association complexes of sibutramine with sodium tetraphenylborate (NaTPB) or phosphotungstic acid (PTA) using dibutyl phthalate as plasticizing solvent. The sensors display a fast, stable response over the concentration range 3.84 x 10(-5)-1.00 x 10(-2) M sibutramine hydrochloride monohydrate (SibuCl), with cationic slopes of 57.7 +/- 0.57 and 59.7 +/- 1.79 mV concentration decade(-1) and detection limits of 8.91 x 10(-6) and 1.47 x 10(-5) M in case of sibutramine-tetraphenylborate (Sibu-TPB) and sibutramine-phosphotungstate ((Sibu)(3)-PT), respectively. The proposed sensors have been successfully applied for the determination of sibutramine hydrochloride in Regitrim capsules in batch and flow injection (FI) conditions.

摘要

描述了用于测定盐酸西布曲明的两种新型聚氯乙烯（PVC）膜传感器的构建及其电化学响应特性。这些传感器基于西布曲明与四苯硼酸钠（NaTPB）或磷钨酸（PTA）形成的离子缔合物，使用邻苯二甲酸二丁酯作为增塑溶剂。在3.84×10⁻⁵ - 1.00×10⁻² M盐酸西布曲明一水合物（SibuCl）浓度范围内，传感器呈现快速、稳定的响应，对于西布曲明 - 四苯硼酸盐（Sibu - TPB）和西布曲明 - 磷钨酸盐（(Sibu)₃ - PT），阳离子斜率分别为57.7 ± 0.57和59.7 ± 1.79 mV/浓度十年⁻¹，检测限分别为8.91×10⁻⁶和1.47×10⁻⁵ M。所提出的传感器已成功应用于在批量和流动注射（FI）条件下测定瑞吉曲明胶囊中的盐酸西布曲明。