Eliasson Charlotte, Matousek Pavel
Central Laser Facility, CCLRC Rutherford Appleton Laboratory, Didcot, Oxfordshire, OX11 0QX, UK.
Anal Chem. 2007 Feb 15;79(4):1696-701. doi: 10.1021/ac062223z.
We demonstrate the use of spatially offset Raman spectroscopy (SORS) in the identification of counterfeit pharmaceutical tablets and capsules through different types of packaging. The technique offers a substantially higher sensitivity than that available from conventional backscattering Raman spectroscopy. The approach is particularly beneficial in situations where the conventional Raman backscattering method is hampered or fails because of excessive surface Raman or fluorescence signals emanating from the packaging, capsule shell, or tablet coating contaminating the much weaker subsurface Raman signals of the active pharmaceutical ingredients and excipients held in the product. It is demonstrated that such interfering signals can be effectively suppressed by SORS.
我们展示了空间偏移拉曼光谱（SORS）在通过不同类型包装识别假冒药品片剂和胶囊方面的应用。该技术提供的灵敏度比传统背散射拉曼光谱高得多。在传统拉曼背散射方法因包装、胶囊壳或片剂包衣产生的过多表面拉曼或荧光信号干扰而受阻或失效的情况下，这种方法特别有用，这些干扰信号会污染产品中活性药物成分和辅料的弱得多的次表面拉曼信号。结果表明，SORS可以有效抑制此类干扰信号。
