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Maternal acceptance of the fetus: true human tolerance.母亲对胎儿的接纳：真正的人类耐受性。
J Immunol. 2007 Mar 15;178(6):3345-51. doi: 10.4049/jimmunol.178.6.3345.
2
The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447].蠕虫对乌干达儿童免疫接种反应以及感染和疾病发生率的影响：一项关于孕期和幼儿期驱虫干预措施的随机、双盲、安慰剂对照、析因试验的设计[国际标准随机对照试验编号：ISRCTN32849447]
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Immune cells in uteroplacental tissues throughout pregnancy: a brief review.孕期子宫胎盘组织中的免疫细胞：简要综述
Reprod Biomed Online. 2007 Feb;14(2):256-66. doi: 10.1016/s1472-6483(10)60796-1.
4
Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases.妊娠诱导的Th2免疫偏移：自身免疫性风湿疾病的两面性
Reprod Toxicol. 2006 Aug;22(2):234-41. doi: 10.1016/j.reprotox.2006.04.001. Epub 2006 May 15.
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Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans.人类慢性曼氏血吸虫病期间与汇管区周围纤维化相关的细胞因子产生
Infect Immun. 2006 Feb;74(2):1215-21. doi: 10.1128/IAI.74.2.1215-1221.2006.
6
Applied and basic research on the epidemiology, morbidity, and immunology of schistosomiasis in fishing communities on Lake Albert, Uganda.乌干达艾伯特湖渔业社区血吸虫病流行病学、发病率及免疫学的应用研究与基础研究
Trans R Soc Trop Med Hyg. 2006 Mar;100(3):216-23. doi: 10.1016/j.trstmh.2005.03.016. Epub 2005 Dec 15.
7
Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni.肯尼亚学龄儿童在接受吡喹酮治疗并大幅减少曼氏血吸虫暴露三年后肝脾肿大的消退情况。
Trans R Soc Trop Med Hyg. 2005 Feb;99(2):150-60. doi: 10.1016/j.trstmh.2004.06.009.
8
Immunopathogenesis of schistosomiasis.血吸虫病的免疫发病机制
Immunol Rev. 2004 Oct;201:156-67. doi: 10.1111/j.0105-2896.2004.00176.x.
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Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel.用吡喹酮治疗可诱导人类辅助性T细胞2细胞因子对曼氏血吸虫虫体和虫体表膜抗原的反应增加。
J Infect Dis. 2004 Aug 15;190(4):835-42. doi: 10.1086/422604. Epub 2004 Jul 12.
10
Th1/Th2 cytokine patterns and clinical profiles during and after pregnancy in women with multiple sclerosis.多发性硬化症女性孕期及产后的Th1/Th2细胞因子模式与临床特征
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孕期使用吡喹酮治疗对血吸虫抗原细胞因子反应的影响：一项随机、安慰剂对照试验的结果

Effect of praziquantel treatment during pregnancy on cytokine responses to schistosome antigens: results of a randomized, placebo-controlled trial.

作者信息

Tweyongyere Robert, Mawa Patrice A, Ngom-Wegi Sophy, Ndibazza Juliet, Duong Trinh, Vennervald Birgitte J, Dunne David W, Katunguka-Rwakishaya Eli, Elliott Alison M

机构信息

Medical Research Council/Uganda Virus Research-Institute Uganda Research Unit on AIDS, Entebbe, Uganda.

出版信息

J Infect Dis. 2008 Dec 15;198(12):1870-9. doi: 10.1086/593215.

DOI:10.1086/593215
PMID:18983246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2892302/
Abstract

BACKGROUND

Praziquantel treatment of schistosomiasis boosts antischistosome responses, with type 2 helper T cell bias that may contribute to immunologically mediated killing and to protection against reinfection. Praziquantel treatment during pregnancy was recommended in 2002, but the immunological effects of the treatment had not been investigated.

METHODS

A cohort of 387 Schistosoma mansoni-infected women were recruited from a larger trial of deworming during pregnancy. Women were randomized to receive either praziquantel or placebo during pregnancy. Six weeks after delivery, all women received praziquantel. Cytokine responses to S. mansoni worm and egg antigens were measured in whole blood culture before and 6 weeks after each treatment.

RESULTS

Schistosome-specific cytokine responses were suppressed during pregnancy. Praziquantel treatment during pregnancy caused significant boosts in interferon-gamma (IFN-gamma), interleukin (IL)-2, IL-4, IL-5, IL-13, and IL-10 responses to schistosome worm antigen and in IFN-gamma, IL-5, and IL-13 responses to schistosome egg antigen, but these boosts were not as substantial as those seen for women treated after delivery.

CONCLUSION

Pregnancy suppresses a potentially beneficial boost in cytokine responses associated with praziquantel treatment. Further studies are needed on the long-term effects that treatment of schistosomiasis during pregnancy have on morbidity and resistance to reinfection among treated women and their offspring.

摘要

背景

吡喹酮治疗血吸虫病可增强抗血吸虫反应，伴有2型辅助性T细胞偏向，这可能有助于免疫介导的杀伤作用以及预防再感染。2002年推荐在孕期使用吡喹酮治疗，但该治疗的免疫学效应尚未得到研究。

方法

从一项更大规模的孕期驱虫试验中招募了387名感染曼氏血吸虫的女性。这些女性被随机分为在孕期接受吡喹酮或安慰剂治疗。分娩后六周，所有女性均接受吡喹酮治疗。在每次治疗前及治疗后6周，于全血培养中测量对曼氏血吸虫虫体和虫卵抗原的细胞因子反应。

结果

孕期血吸虫特异性细胞因子反应受到抑制。孕期接受吡喹酮治疗使对血吸虫虫体抗原的干扰素-γ（IFN-γ）、白细胞介素（IL）-2、IL-4、IL-5、IL-13和IL-10反应以及对血吸虫虫卵抗原的IFN-γ、IL-5和IL-13反应显著增强，但这些增强程度不如产后接受治疗的女性明显。

结论

孕期会抑制与吡喹酮治疗相关的细胞因子反应的潜在有益增强。需要进一步研究孕期治疗血吸虫病对接受治疗的女性及其后代的发病率和再感染抵抗力的长期影响。