Voss Joachim, Portillo Carmen J, Holzemer William L, Dodd Marylin J
National Institutes of Health, National Institute of Neurological Disorders and Stroke, Neuromuscular Diseases Section, Building 10, Center Drive, Bethesda, MD 20892-1382, USA.
J Prev Interv Community. 2007;33(1-2):19-34. doi: 10.1300/J005v33n01_03.
Fatigue and depression are among the most frequently rated symptoms of people with HIV/AIDS. This study aimed: (1) to describe severity of fatigue and depression in an outpatient sample (n=372) of men and women with HIV/AIDS, (2) to evaluate sensitivity and discriminant validity for two fatigue and three depression scales and (3) to investigate whether fatigue and depression are conceptually distinct concepts or reciprocally dependent. This was a secondary analysis of a descriptive, cross-sectional study with convenience sampling. Fatigue was assessed with the fatigue factor score of the revised Sign and Symptom Checklist HIV (SSC-HIVrev), and the fatigue scale of the Self-Care Symptom Management for Living with HIV/AIDS Scale SCSMS-F). Depression was assessed with the depression factor score of the SSC-HIVrev, the depression scale of the SCSMC-D and the Center for Epidemiologic Studies Depression Scale (CES-D). Most of the participants were male (67%), with a mean age of 39.9 years, and of African American decent (73%). Dependent on the instrument, the average fatigue severity was moderate and the average depression severity was moderate to severe. Women experienced higher fatigue and depression severity scores than men. The scores on the same instruments for fatigue and depression showed significant correlations (SSC-HIVrev fatigue and depression r=0.62; SCSMS fatigue and depression r=0.64), indicating that both concepts are closely related. Patients seeking help for fatigue and/or depression should always be evaluated for both symptoms. Future research is needed to identify dimensions in different fatigue and depression scales in order to differentiate the impact of both symptoms on people living with HIV/AIDS.
疲劳和抑郁是艾滋病毒/艾滋病患者最常被提及的症状。本研究旨在：（1）描述艾滋病毒/艾滋病门诊样本（n = 372）中男性和女性的疲劳和抑郁严重程度，（2）评估两种疲劳量表和三种抑郁量表的敏感性和判别效度，以及（3）调查疲劳和抑郁在概念上是不同的概念还是相互依存的。这是一项采用便利抽样的描述性横断面研究的二次分析。使用修订后的艾滋病毒体征和症状清单（SSC-HIVrev）的疲劳因子得分以及艾滋病毒/艾滋病自我护理症状管理量表（SCSMS-F）的疲劳量表评估疲劳。使用SSC-HIVrev的抑郁因子得分、SCSMC-D的抑郁量表和流行病学研究中心抑郁量表（CES-D）评估抑郁。大多数参与者为男性（67%），平均年龄39.9岁，非裔美国人后裔占73%。根据所使用的工具，平均疲劳严重程度为中度，平均抑郁严重程度为中度至重度。女性的疲劳和抑郁严重程度得分高于男性。同一工具上的疲劳和抑郁得分显示出显著相关性（SSC-HIVrev疲劳和抑郁r = 0.62；SCSMS疲劳和抑郁r = 0.64），表明这两个概念密切相关。因疲劳和/或抑郁寻求帮助的患者应始终对这两种症状进行评估。未来需要开展研究，以确定不同疲劳和抑郁量表中的维度，以便区分这两种症状对艾滋病毒/艾滋病患者的影响。
