Ulamec Monika, Tomas Davor, Ensinger Christian, Cupic Hrvoje, Belicza Mladen, Mikuz Gregor, Kruslin Bozo
Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia.
J Clin Pathol. 2007 Oct;60(10):1098-101. doi: 10.1136/jcp.2006.044784. Epub 2007 Feb 13.
To evaluate the presence and extent of periacinar retraction clefting in proliferative prostatic atrophy and carcinoma in radical prostatectomy specimens.
Atrophic foci and neoplastic glands were analysed in specimens from 50 patients who underwent radical prostatectomy. Analysed atrophic glands were classified in two main groups, proliferative atrophy (PA) and proliferative inflammatory atrophy (PIA); each group was subclassified into simple atrophy (SA) and postatrophic hyperplasia (PAH). According to the presence and extent of periacinar retraction clefting, atrophic and neoplastic glands were classified as: group 1, glands without clefts or with clefts affecting <or=50% of gland circumference; group 2, glands with clefts that affected >50% of the circumference in <50% of examined glands; and group 3, glands with clefts that affected >50% of the circumference in >or=50% of examined glands.
Forty-four (88.0%) atrophic foci were without periacinar clefts or clefts were present in less than half of the gland circumference (group 1). In 6 (12.0%), atrophic foci clefts affected >50% of gland circumference (groups 2 and 3). Forty-five (90.0%) carcinomas were with clefts which affected more than 50% of gland circumference (groups 2 and 3); and in five carcinomas only, clefts were not found or affected <50% of gland circumference (group 1).
Results indicate that periacinar retraction clefting represents a reliable criterion in differential diagnosis between proliferative atrophy and carcinoma.
评估根治性前列腺切除标本中增生性前列腺萎缩及癌组织腺泡周围退缩裂隙的存在情况及范围。
对50例行根治性前列腺切除术患者的标本中的萎缩灶及肿瘤腺体进行分析。所分析的萎缩腺体分为两大组，即增生性萎缩（PA）和增生性炎性萎缩（PIA）；每组再细分为单纯萎缩（SA）和萎缩后增生（PAH）。根据腺泡周围退缩裂隙的存在情况及范围，将萎缩和肿瘤腺体分为：1组，无裂隙或裂隙累及腺周<或=50%的腺体；2组，裂隙累及<50%被检查腺体的>50%腺周的腺体；3组，裂隙累及>或=50%被检查腺体的>50%腺周的腺体。
44个（88.0%）萎缩灶无腺泡周围裂隙或裂隙存在于不到一半的腺周（1组）。6个（12.0%）萎缩灶的裂隙累及>50%的腺周（2组和3组）。45个（90.0%）癌组织有裂隙累及>50%的腺周（2组和3组）；仅5个癌组织未发现裂隙或裂隙累及<50%的腺周（1组）。
结果表明腺泡周围退缩裂隙是增生性萎缩与癌鉴别诊断的可靠标准。
