Murphy G P, Williams P D, Mirand E A
J Surg Oncol. 1976;8(2):131-5. doi: 10.1002/jso.2930080207.
Erythropoietin (ESF) levels were assayed in rats bearing the Wistar-Furth Wilms' transplantable tumor. Sites of tumor inoculation varied from subcutaneous, intramuscular, intrarenal (subcapsular), to intraperitoneal. Two-thirds of the animals exhibited ESF elevations without polycythemia, or severe anemia (HCT less than 30.0 vol%). The elevations of ESF were not detectably related to the time of sacrifice (age of the animal), size of the primary tumor, or number of gross metastatic foci. The diminished ESF response noted to animals given intramuscular tumor implantations is believed to reflect differences in tumor blood and lymphatic supply at the various sites of inoculation. The pattern of ESF responses in the Wistar-Furth Wilms' tumor model is thus quite similar to that which we have observed in man, and appears to represent an animal model for tumor-related ectopic hormone release. The nature of the hormone is believed to differ from that seen in normal physiological states.
对携带Wistar-Furth可移植性肾母细胞瘤的大鼠进行了促红细胞生成素（ESF）水平检测。肿瘤接种部位包括皮下、肌肉内、肾内（被膜下）和腹腔内。三分之二的动物出现ESF升高，但无红细胞增多症或严重贫血（血细胞比容低于30.0%容积）。ESF升高与处死时间（动物年龄）、原发肿瘤大小或肉眼可见转移灶数量无明显相关性。肌肉内接种肿瘤的动物ESF反应减弱，这被认为反映了不同接种部位肿瘤血液和淋巴供应的差异。因此，Wistar-Furth肾母细胞瘤模型中的ESF反应模式与我们在人类中观察到的模式非常相似，似乎代表了一种肿瘤相关异位激素释放的动物模型。据信该激素的性质与正常生理状态下所见的不同。
