Ahveninen Jyrki, Lin Fa-Hsuan, Kivisaari Reetta, Autti Taina, Hämäläinen Matti, Stufflebeam Steven, Belliveau John W, Kähkönen Seppo
Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School-Athinoula A. Martinos Center for Biomedical Imaging, CNY149 13th Street, Charlestown, MA 02129, USA.
Neuroimage. 2007 Apr 1;35(2):577-82. doi: 10.1016/j.neuroimage.2006.12.033. Epub 2007 Jan 10.
Spontaneous electromagnetic brain rhythms have been widely used in human neuropharmacology, but their applicability is complicated by the difficulties to localize their origins in the human cortex. Here, we used a novel multi-modal non-invasive imaging approach to localize lorazepam (30 microg/kg i.v.) modulation of cortical generators of spontaneous brain rhythms. Eight healthy subjects were measured with 306-channel magnetoencephalography (MEG) in a double-blind, randomized, placebo-controlled (saline), crossover design. For anatomically realistic source modeling, wavelet-transformed MEG data were combined with high-resolution MRI to constrain the current locations to the cortical mantle, after which individual data were co-registered to surface-based coordinate system for the calculation of group statistical parametric maps of drug effects. The distributed MRI-constrained MEG source estimates demonstrated decreased alpha (10 Hz) activity in and around the parieto-occipital sulcus and in the calcarine sulcus of the occipital lobe, following from increased GABA(A)-inhibition by lorazepam. Anatomically constrained spectral imaging displays the cortical loci of drug effects on oscillatory brain activity, providing a novel tool for human pharmacological neuroimaging.
自发性脑电节律已在人类神经药理学中广泛应用，但其应用因难以在人类皮层中定位其起源而变得复杂。在此，我们采用一种新型多模态非侵入性成像方法来定位劳拉西泮（静脉注射30微克/千克）对自发性脑节律皮层发生器的调节作用。八名健康受试者在双盲、随机、安慰剂对照（生理盐水）、交叉设计中接受306通道脑磁图（MEG）测量。为进行解剖学上真实的源建模，将小波变换后的MEG数据与高分辨率MRI相结合，将电流位置限制在皮层表面，之后将个体数据共同配准到基于表面的坐标系，以计算药物效应的组统计参数图。分布的MRI约束MEG源估计显示，劳拉西泮增加GABA(A)抑制作用后，顶枕沟及其周围以及枕叶距状沟中的α（10赫兹）活动减少。解剖学约束光谱成像显示了药物对振荡脑活动影响的皮层位点，为人类药理学神经成像提供了一种新工具。
