Xiang Jing, Liu Yang, Wang Yingying, Kotecha Rupesh, Kirtman Elijah G, Chen Yangmei, Huo Xiaolin, Fujiwara Hisako, Hemasilpin Nat, DeGrauw Ton, Rose Douglas
MEG Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45220, USA.
Brain Res. 2009 Jun 5;1274:28-39. doi: 10.1016/j.brainres.2009.03.068. Epub 2009 Apr 9.
Recent studies have found that the brain generates very fast oscillations. The objective of the present study was to investigate the spectral, spatial and coherent features of high-frequency brain oscillations in the developing brain. Sixty healthy children and 20 healthy adults were studied using a 275-channel magnetoencephalography (MEG) system. MEG data were digitized at 12,000 Hz. The frequency characteristics of neuromagnetic signals in 0.5-2000 Hz were quantitatively determined with Morlet wavelet transform. The magnetic sources were volumetrically estimated with wavelet-based beamformer at 2.5 mm resolution. The neural networks of endogenous brain oscillations were analyzed with coherent imaging. Neuromagnetic activities in 8-12 Hz and 800-900 Hz were found to be the most reliable frequency bands in healthy children. The neuromagnetic signals were localized in the occipital, temporal and frontal cortices. The activities in the occipital and temporal cortices were strongly correlated in 8-12 Hz but not in 800-900 Hz. In comparison to adults, children had brain oscillations in intermingled frequency bands. Developmental changes in children were identified for both low- and high-frequency brain activities. The results of the present study suggest that the development of the brain is associated with spatial and coherent changes of endogenous brain activities in both low- and high-frequency ranges. Analysis of high-frequency neuromagnetic oscillation may provide novel insights into cerebral mechanisms of brain function. The noninvasive measurement of neuromagnetic brain oscillations in the developing brain may open a new window for analysis of brain function.
最近的研究发现，大脑会产生非常快速的振荡。本研究的目的是调查发育中大脑高频脑振荡的频谱、空间和相干特征。使用275通道脑磁图（MEG）系统对60名健康儿童和20名健康成人进行了研究。MEG数据以12000Hz的频率数字化。采用Morlet小波变换定量测定0.5 - 2000Hz神经磁信号的频率特征。使用基于小波的波束形成器以2.5mm的分辨率对磁源进行体积估计。通过相干成像分析内源性脑振荡的神经网络。发现8 - 12Hz和800 - 900Hz的神经磁活动是健康儿童中最可靠的频段。神经磁信号定位于枕叶、颞叶和额叶皮质。枕叶和颞叶皮质的活动在8 - 12Hz时强烈相关，但在800 - 900Hz时不相关。与成人相比，儿童的脑振荡存在于混合频段。确定了儿童低频和高频脑活动的发育变化。本研究结果表明，大脑的发育与低频和高频范围内内源性脑活动的空间和相干变化有关。高频神经磁振荡分析可能为脑功能的脑机制提供新的见解。对发育中大脑神经磁振荡的无创测量可能为脑功能分析打开一扇新窗口。
