Nebes Robert D, Pollock Bruce G, Halligan Edythe M, Kirshner Margaret A, Houck Patricia R
Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA.
J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):83-5. doi: 10.1093/gerona/62.1.83.
Medications prescribed to elderly persons often have an anticholinergic effect, as do many commonly used over-the-counter drugs. Anticholinergic medications are known to produce psychomotor slowing, especially in older persons.
The present study examined whether the cumulative anticholinergic load present in the serum of community volunteers was associated with decrements on tests of psychomotor performance (gait speed and simple manual response time) known to predict falls in elderly persons.
Serum anticholinergic activity (SAA) was relatively low in this group; however, an elevated SAA was associated with a significant slowing in both gait speed and simple response time.
Cumulative anticholinergic burden may be one of the factors contributing to an increased risk of falls in the older population.
开给老年人的药物通常具有抗胆碱能作用，许多常用的非处方药也是如此。已知抗胆碱能药物会导致精神运动迟缓，尤其是在老年人中。
本研究调查了社区志愿者血清中存在的累积抗胆碱能负荷是否与已知可预测老年人跌倒的精神运动表现测试（步速和简单手动反应时间）的下降有关。
该组血清抗胆碱能活性（SAA）相对较低；然而，SAA升高与步速和简单反应时间的显著减慢有关。
累积抗胆碱能负担可能是导致老年人群跌倒风险增加的因素之一。
