Jones A C, Berman P, Doherty M
Department of Health Care of the Elderly, City Hospital, Nottingham.
Br J Rheumatol. 1992 Jan;31(1):45-8. doi: 10.1093/rheumatology/31.1.45.
There is a strong feeling that despite the increasing awareness of their adverse effects, non-steroidal anti-inflammatory drugs (NSAIDs) are not always used appropriately. To examine this problem amongst elderly patients who may be at particular risk, 500 acute admissions to Health Care of the Elderly wards were studied prospectively. Sixty-five patients were currently receiving NSAIDs; 56 had medical conditions possibly caused by, or aggravated by NSAIDs. Indications for NSAIDs were often no longer apparent, and these drugs were successfully discontinued in 56; in 22 no alternative therapy was required. Importantly, following discharge the majority of patients remained off NSAIDs. These data support the need for continual review of NSAID requirements and regular monitoring for adverse effects, particularly in this high risk group.
尽管人们越来越意识到非甾体抗炎药（NSAIDs）的不良反应，但仍有一种强烈的感觉，即这些药物的使用并不总是恰当的。为了研究这个问题在可能面临特殊风险的老年患者中的情况，我们对500例入住老年保健病房的急性患者进行了前瞻性研究。65例患者正在服用NSAIDs；56例有可能由NSAIDs引起或因NSAIDs而加重的疾病。使用NSAIDs的指征往往不再明显，56例患者成功停用了这些药物；22例患者无需替代治疗。重要的是，出院后大多数患者仍未服用NSAIDs。这些数据支持了持续审查NSAIDs需求并定期监测不良反应的必要性，尤其是在这个高风险群体中。
