Cheng Iona, Plummer Sarah J, Casey Graham, Witte John S
Department of Epidemiology and Biostatistics and Center of Human Genetics, University of California at San Francisco, 94143-0794, USA.
Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):352-5. doi: 10.1158/1055-9965.EPI-06-0429.
Toll-like receptor 4 (TLR4) is a key innate immunity receptor that initiates an inflammatory response primarily against Gram-negative bacteria. Two recent publications reported that variants in TLR4 were associated with risk of prostate cancer. To further investigate the role of TLR4 in prostate cancer susceptibility, we identified six tagging single-nucleotide polymorphisms that comprehensively captured the common genetic variation of the locus and tested these polymorphisms in our case-control study of 1,012 men. Two single-nucleotide polymorphisms showed nominally statistically significant associations with prostate cancer risk, with the strongest (rs10759932) associated with a 4-fold increased risk of disease (P = 0.006). We estimated through permutation analysis that a similarly strong result would occur by chance 2.5% of the time. Our findings support previous studies and suggest that inherited differences in TLR4 influence prostate cancer risk.
Toll样受体4（TLR4）是一种关键的固有免疫受体，主要引发针对革兰氏阴性菌的炎症反应。最近的两篇出版物报道，TLR4中的变异与前列腺癌风险相关。为了进一步研究TLR4在前列腺癌易感性中的作用，我们鉴定了六个标签单核苷酸多态性，这些多态性全面捕获了该基因座的常见遗传变异，并在我们对1012名男性的病例对照研究中对这些多态性进行了检测。两个单核苷酸多态性与前列腺癌风险呈现出名义上具有统计学意义的关联，其中最强的（rs10759932）与疾病风险增加4倍相关（P = 0.006）。我们通过置换分析估计，类似强度的结果偶然出现的概率为2.5%。我们的研究结果支持先前的研究，并表明TLR4的遗传差异会影响前列腺癌风险。
