Chao C C, Strgar F, Tsang M, Peterson P K
Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota.
Clin Immunol Immunopathol. 1992 Feb;62(2):220-6. doi: 10.1016/0090-1229(92)90075-y.
The effects of swimming exercise on the pathogenesis of acute murine toxoplasma infection were studied. Swimming (45 min/day) initiated on the day of inoculation with the avirulent Me49 strain of Toxoplasma gondii did not alter survival of infected mice. At a later stage of infection, daily swimming appeared to promote the recovery of appetite and weight gain. Immune activation was apparent in toxoplasma-infected mice, and swimming blunted splenic enlargement but not the respiratory burst activity of peritoneal exudate cells. Infection caused a significant elevation of serum tumor necrosis factor (TNF) levels which was attenuated by a daily swimming program. These data show that swimming exercise is not deleterious to mice acutely infected with T. gondii Me49 and that the more rapid recovery in exercised mice is associated with reduced serum TNF levels.
研究了游泳锻炼对急性鼠弓形虫感染发病机制的影响。在接种无毒力的刚地弓形虫Me49株当天开始游泳（每天45分钟），并未改变感染小鼠的存活率。在感染后期，每日游泳似乎促进了食欲恢复和体重增加。弓形虫感染的小鼠出现免疫激活，游泳可减轻脾脏肿大，但对腹腔渗出细胞的呼吸爆发活性无影响。感染导致血清肿瘤坏死因子（TNF）水平显著升高，而每日游泳计划可使其降低。这些数据表明，游泳锻炼对急性感染刚地弓形虫Me49的小鼠无害，且运动小鼠恢复更快与血清TNF水平降低有关。
