Meyskens Frank L, Farmer Patrick J, Yang Sun, Anton-Culver Hoda
University of California, Irvine, Orange 92868, USA.
Recent Results Cancer Res. 2007;174:191-5. doi: 10.1007/978-3-540-37696-5_16.
Epidemiologic studies implicate ultraviolet radiation (sunlight) as an etiologic agent for the pathogenesis of melanoma. However, the experimental evidence is less convincing. We present information from recent experimental findings that elevation of reactive oxygen species follows from melanin serving as a redox generator, and that this may play an important role in the etiology and pathogenesis of cutaneous melanoma. These observations offer a new paradigm for the development of preventive (and therapeutic) approaches to this disease.
流行病学研究表明，紫外线辐射（阳光）是黑色素瘤发病机制的病因。然而，实验证据却不那么令人信服。我们提供了近期实验结果的相关信息，即黑色素作为氧化还原发生器会导致活性氧物质增加，而这可能在皮肤黑色素瘤的病因和发病机制中发挥重要作用。这些观察结果为该疾病预防（和治疗）方法的开发提供了新的范例。
