Pilz Stefan, Weihrauch Gisela, Seelhorst Ursula, Wellnitz Britta, Winkelmann Bernhard R, Boehm Bernhard O, März Winfried
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
Clin Endocrinol (Oxf). 2007 Mar;66(3):380-6. doi: 10.1111/j.1365-2265.2007.02743.x.
The adipokine resistin, which is thought to serve as a link between obesity and insulin resistance, was recently shown to exert proatherosclerotic features.
Our study aimed to explore the involvement of resistin in cardiovascular disease by investigating the associations of resistin with angiographic coronary artery disease (CAD), cardiovascular risk factors and mortality.
The Ludwigshafen Risk and Cardiovascular Health (LURIC) study is a prospective study of white subjects who had undergone coronary angiography.
Resistin levels were determined in 1162 subjects with (n = 911) and without (n = 251) angiographic CAD. During a mean follow-up period of 5.47 years, 198 deaths occurred among our probands.
Resistin was positively correlated with C-reactive protein (CRP; r = 0.245, P < 0.001), vascular adhesion molecule-1 (VCAM-1; r = 0.327, P < 0.001) and intercellular adhesion molecule-1 (ICAM-1; r = 0.197, P < 0.001) and was negatively correlated with glomerular filtration rate (GFR; r = -0.438, P < 0.001) and high density lipoprotein (HDL; r = -0.196, P < 0.001). Multiple regression analysis revealed that GFR was the strongest predictive variable for resistin. Angiographic CAD, type 2 diabetes, smoking, hypertension and body mass index (BMI) were not associated with resistin. Compared to the first quartile, we observed an increased risk for cardiovascular and noncardiovascular mortality at the fourth quartile of resistin, but only the association between resistin and noncardiovascular mortality remained significant after multivariable adjustments [hazard ratio (HR) 4.92, 95% confidence interval (CI) 1.66-14.6, P = 0.004].
Resistin plasma concentrations are related to inflammatory processes and renal function but our study does not support the hypothesis of resistin as an independent cardiovascular risk factor. The unexpected association of resistin with noncardiovascular mortality still warrants further study.
脂肪因子抵抗素被认为是肥胖与胰岛素抵抗之间的联系纽带，最近研究表明其具有动脉粥样硬化的特征。
我们的研究旨在通过调查抵抗素与冠状动脉造影冠心病（CAD）、心血管危险因素及死亡率之间的关联，来探究抵抗素在心血管疾病中的作用。
路德维希港风险与心血管健康（LURIC）研究是一项针对接受冠状动脉造影的白人受试者的前瞻性研究。
在1162名有（n = 911）和无（n = 251）冠状动脉造影CAD的受试者中测定抵抗素水平。在平均5.47年的随访期内，我们的先证者中有198例死亡。
抵抗素与C反应蛋白（CRP；r = 0.245，P < 0.001）、血管细胞黏附分子-1（VCAM-1；r = 0.327，P < 0.001）和细胞间黏附分子-1（ICAM-1；r = 0.197，P < 0.001）呈正相关，与肾小球滤过率（GFR；r = -0.438，P < 0.001）和高密度脂蛋白（HDL；r = -0.196，P < 0.001）呈负相关。多元回归分析显示，GFR是抵抗素最强的预测变量。冠状动脉造影CAD、2型糖尿病、吸烟、高血压和体重指数（BMI）与抵抗素无关。与第一四分位数相比，我们观察到在抵抗素第四四分位数时心血管和非心血管死亡风险增加，但多变量调整后仅抵抗素与非心血管死亡之间的关联仍具有统计学意义[风险比（HR）4.92，95%置信区间（CI）1.66 - 14.6，P = 0.004]。
抵抗素血浆浓度与炎症过程和肾功能有关，但我们的研究不支持抵抗素作为独立心血管危险因素的假说。抵抗素与非心血管死亡之间意外的关联仍值得进一步研究。
