University of Leipzig, Department of Obstetrics, Leipzig, Germany.
J Endocrinol Invest. 2012 Jun;35(6):562-5. doi: 10.3275/7877. Epub 2011 Jul 27.
Preeclampsia (PE) is associated with facets of the metabolic syndrome and an increased future metabolic and cardiovascular risk for mother and newborn. Recently, zinc-α2-glycoprotein (ZAG) has been proposed as a new adipokine involved in the pathogenesis of obesity.
In the current study, we investigated ZAG serum levels in PE patients as compared to healthy gestational age-matched controls.
We quantified serum concentrations of ZAG in patients with PE (no.=37) as compared to healthy gestational age-matched controls (no.=37) by enzyme-linked immunosorbent assay. Furthermore, association of this adipokine with renal function, glucose and lipid metabolism, as well as inflammation was studied.
Median serum ZAG levels were 1.4-fold higher in PE patients (58.8 mg/l) as compared to controls (41.9 mg/l) (p<0.01). Furthermore, circulating ZAG was positively correlated to systolic and diastolic blood pressure, creatinine, triglycerides, and leptin in univariate analyses. In multiple regression analysis, creatinine remained independently associated with ZAG.
We demonstrate that maternal ZAG serum concentrations are significantly increased in PE. Furthermore, renal function is an independent predictor of circulating ZAG.
子痫前期（PE）与代谢综合征的各个方面有关，并且母亲和新生儿未来的代谢和心血管风险增加。最近，锌-α2-糖蛋白（ZAG）被提议作为一种新的脂肪因子，参与肥胖的发病机制。
在本研究中，我们比较了健康妊娠年龄匹配的对照组，调查了 PE 患者的 ZAG 血清水平。
我们通过酶联免疫吸附试验定量了 37 例 PE 患者和 37 例健康妊娠年龄匹配的对照组的血清 ZAG 浓度。此外，还研究了这种脂肪因子与肾功能、葡萄糖和脂质代谢以及炎症的相关性。
PE 患者的血清 ZAG 水平中位数（58.8mg/l）比对照组（41.9mg/l）高 1.4 倍（p<0.01）。此外，在单变量分析中，循环 ZAG 与收缩压和舒张压、肌酐、甘油三酯和瘦素呈正相关。在多元回归分析中，肌酐仍然与 ZAG 独立相关。
我们证明母体 ZAG 血清浓度在 PE 中显著增加。此外，肾功能是循环 ZAG 的独立预测因子。
