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Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis.

作者信息

Inagaki Y, Okazaki I

机构信息

Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259-1193, Japan.

出版信息

Gut. 2007 Feb;56(2):284-92. doi: 10.1136/gut.2005.088690.

DOI:10.1136/gut.2005.088690
PMID:17303605
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1856752/
Abstract
摘要

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本文引用的文献

1
The bone marrow functionally contributes to liver fibrosis.骨髓在功能上对肝纤维化有影响。
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2
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets.现代肝纤维化发病机制概念表明，星状细胞和转化生长因子-β是主要参与者和治疗靶点。
J Cell Mol Med. 2006 Jan-Mar;10(1):76-99. doi: 10.1111/j.1582-4934.2006.tb00292.x.
3
Smad transcription factors.Smad转录因子。
Genes Dev. 2005 Dec 1;19(23):2783-810. doi: 10.1101/gad.1350705.
4
Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects.Y盒蛋白1是抗纤维化γ干扰素效应的关键介质。
J Biol Chem. 2006 Jan 20;281(3):1784-95. doi: 10.1074/jbc.M510215200. Epub 2005 Nov 8.
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Transforming growth factor-beta signaling in stem cells and cancer.干细胞与癌症中的转化生长因子-β信号传导
Science. 2005 Oct 7;310(5745):68-71. doi: 10.1126/science.1118389.
6
BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2.骨形态发生蛋白-7通过Id2抑制小鼠肺肌成纤维细胞中转化生长因子-β1介导的胶原蛋白诱导。
Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L120-6. doi: 10.1152/ajplung.00171.2005. Epub 2005 Aug 26.
7
Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.转化生长因子β/ Smad信号通路的细胞类型特异性干预可抑制小鼠胶原蛋白基因表达和肝纤维化。
Gastroenterology. 2005 Jul;129(1):259-68. doi: 10.1053/j.gastro.2005.03.088.
8
Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization.Smad2和Smad3在大鼠肝星状细胞功能及α-平滑肌肌动蛋白组织中发挥不同作用。
Mol Biol Cell. 2005 Sep;16(9):4214-24. doi: 10.1091/mbc.e05-02-0149. Epub 2005 Jun 29.
9
Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells.血小板反应蛋白1通过两种不同机制，在肝星状细胞中作为转化生长因子β效应的强力促进因子。
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Am J Pathol. 2005 Apr;166(4):1029-39. doi: 10.1016/s0002-9440(10)62324-3.