Coppinger Judith A, O'Connor Roisin, Wynne Kieran, Flanagan Michelle, Sullivan Matthew, Maguire Patricia B, Fitzgerald Desmond J, Cagney Gerard
Department of Cell Biology, Scripps Research Institute, La Jolla, CA, USA.
Blood. 2007 Jun 1;109(11):4786-92. doi: 10.1182/blood-2006-07-038539. Epub 2007 Feb 15.
Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.
激活过程中释放的蛋白质的调节是阿司匹林可能影响血小板介导的人类疾病的一种机制。我们使用质谱法研究了阿司匹林对血小板释放物的影响，发现不同的激动剂会引发不同的释放物谱，无论激动剂如何，阿司匹林对释放的蛋白质量都有普遍的调节作用。使用抗体阵列方法对几种细胞因子进行的研究证实了这些观察结果。
