Human Nutrition & Health, Department of Agrotechnology and Food Sciences, Wageningen University & Research, 6708 WE Wageningen, The Netherlands.
Department of Medical Imaging, Anatomy, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, 6525 EZ Nijmegen, The Netherlands.
Biomolecules. 2021 Oct 4;11(10):1455. doi: 10.3390/biom11101455.
Metabolic syndrome increases the risk of vascular dementia and other neurodegenerative disorders. Recent studies underline that platelets play an important role in linking peripheral with central metabolic and inflammatory mechanisms. In this narrative review, we address the activation of platelets in metabolic syndrome, their effects on neuronal processes and the role of the mediators (e.g., serotonin, platelet-derived growth factor). Emerging evidence shows that nutritional compounds and their metabolites modulate these interactions-specifically, long chain fatty acids, endocannabinoids and phenolic compounds. We reviewed the role of activated platelets in neurovascular processes and nutritional compounds in platelet activation.
代谢综合征会增加血管性痴呆和其他神经退行性疾病的风险。最近的研究强调，血小板在连接外周和中枢代谢及炎症机制方面起着重要作用。在这篇叙述性综述中，我们探讨了代谢综合征中血小板的激活、它们对神经元过程的影响以及介质（如 5-羟色胺、血小板衍生生长因子）的作用。新出现的证据表明，营养化合物及其代谢物调节这些相互作用——具体来说，长链脂肪酸、内源性大麻素和酚类化合物。我们综述了活化血小板在神经血管过程中的作用以及营养化合物在血小板激活中的作用。
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