源自克氏锥虫锥鞭毛体85千道尔顿表面蛋白序列的重复肽的多克隆细胞活性。
Polyclonal cell activity of a repeat peptide derived from the sequence of an 85-kilodalton surface protein of Trypanosoma cruzi trypomastigotes.
作者信息
Pestel J, Defoort J P, Gras-Masse H, Afchain D, Capron A, Tartar A, Ouaissi A
机构信息
Centre d'Immunologie, Unité Mixte INSERM U167-CNRS 624, Institut Pasteur de Lille, France.
出版信息
Infect Immun. 1992 Feb;60(2):715-9. doi: 10.1128/iai.60.2.715-719.1992.
Abstract
Some in vitro and in vivo biological activities of an octadecapeptide derived from an 85-kDa surface protein of Trypanosoma cruzi trypomastigote were studied. The peptide coupled to a carrier protein induced the proliferative response of lymph node cells from mice immunized with various antigens. Moreover, sera from mice immunized with the coupled peptide were found to contain antibodies against a number of self and nonself antigens: fibronectin, bovine serum albumin, myosin, tetanus toxoid, ovalbumin, keyhole limpet hemocyanin, and DNA. These results are discussed in the context of Chagas' disease immunopathology.
摘要
对源自克氏锥虫锥鞭毛体85 kDa表面蛋白的十八肽的一些体外和体内生物学活性进行了研究。与载体蛋白偶联的该肽诱导了用各种抗原免疫的小鼠淋巴结细胞的增殖反应。此外，发现用偶联肽免疫的小鼠血清含有针对多种自身和非自身抗原的抗体：纤连蛋白、牛血清白蛋白、肌球蛋白、破伤风类毒素、卵清蛋白、钥孔戚血蓝蛋白和DNA。在恰加斯病免疫病理学的背景下对这些结果进行了讨论。
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