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克氏锥虫感染人类后抗体反应的抑制。

Suppression of antibody responses in humans infected with Trypanosoma cruzi.

作者信息

Cunningham D S, Grogl M, Kuhn R E

出版信息

Infect Immun. 1980 Nov;30(2):496-9. doi: 10.1128/iai.30.2.496-499.1980.

DOI:10.1128/iai.30.2.496-499.1980
PMID:6777305
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC551339/
Abstract

Peripheral blood leukocytes from patients serologically positive for Chagas' disease were examined for their ability to respond to heterologous antigens in vitro. It was found that mononuclear cells from chagasic patients had greatly reduced ability to respond to sheep erythrocytes (SRBC) as compared with peripheral blood mononuclear cells (PBMC) from control subjects. The reduction in anti-SRBC antibody activity was independent of antigen dose and was not a result of differences in antibody response kinetics. Depletion of plastic-adherent result of differences in antibody response kinetics. Depletion of plastic-adherent cells from the PBMC of patients did not affect the suppressed state of the nonadherent lymphocytes. No relationship was evident between the duration of Trypanosoma cruzi infection and the degree of humoral responsiveness.

摘要

对恰加斯病血清学阳性患者的外周血白细胞进行体外检测，以观察其对异源抗原的反应能力。结果发现，与对照受试者的外周血单个核细胞（PBMC）相比，恰加斯病患者的单个核细胞对绵羊红细胞（SRBC）的反应能力大大降低。抗SRBC抗体活性的降低与抗原剂量无关，也不是抗体反应动力学差异的结果。从患者的PBMC中去除贴壁细胞并不会影响非贴壁淋巴细胞的抑制状态。克氏锥虫感染的持续时间与体液反应程度之间没有明显关系。

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本文引用的文献

1
Trypanosoma cruzi-induced suppression of the primary immune response in murine cell cultures to T-cell-dependent and -independent antigens.克氏锥虫诱导鼠细胞培养物中对T细胞依赖性和非依赖性抗原的原发性免疫应答抑制。
J Parasitol. 1980 Feb;66(1):16-27.
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Trypanosoma cruzi-induced suppressor substance. I. cellular involvement and partial characterization.克氏锥虫诱导的抑制物质。I. 细胞参与及部分特性鉴定
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Fluorescent antibody test for the serodiagnosis of American trypanosomiasis. Technical modification employing preserved culture forms of Trypanosoma cruzi in a slide test.用于美洲锥虫病血清诊断的荧光抗体试验。在玻片试验中采用克氏锥虫保存培养形式的技术改进。
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Plaque forming cells: methodology and theory.噬斑形成细胞：方法与理论
Transplant Rev. 1974;18:130-91. doi: 10.1111/j.1600-065x.1974.tb01588.x.
5
Immune responses in vitro. I. Culture conditions for antibody synthesis.体外免疫反应。I. 抗体合成的培养条件。
Cell Immunol. 1972 Feb;3(2):264-76. doi: 10.1016/0008-8749(72)90165-7.
6
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.从人血中分离单核细胞和粒细胞。通过一次离心分离单核细胞，通过离心和1g沉降相结合的方法分离粒细胞。
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Differential antibody production of adherent and nonadherent spleen cells transferred to irradiated and cyclophosphamide-treated recipient mice.转移至经照射及环磷酰胺处理的受体小鼠体内的贴壁和非贴壁脾细胞的差异抗体产生情况。
J Reticuloendothel Soc. 1975 Apr;17(4):195-209.
8
Induction of an antibody response in cultures of human peripheral blood lymphocytes.人外周血淋巴细胞培养中抗体反应的诱导。
J Exp Med. 1976 Sep 1;144(3):573-85. doi: 10.1084/jem.144.3.573.
9
Trypanosoma cruzi: early immune responses in infected mice.克氏锥虫：感染小鼠的早期免疫反应
Exp Parasitol. 1975 Jun;37(3):417-25. doi: 10.1016/0014-4894(75)90012-0.
10
Suppression of cell-mediated immunity in experimental Chagas' disease.
Z Parasitenkd. 1977 Jun 3;52(1):11-7. doi: 10.1007/BF00380553.

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