Driot J Y, Bonne C
Chauvin Laboratory Research Centre, Montpellier, France.
Invest Ophthalmol Vis Sci. 1992 Jan;33(1):190-5.
We report the effects of CBS-211 A, a synthetic retinoic acid analog, on a previously described experimental model of keratoconjunctivitis sicca (KCS) in the rabbit. A 9-week topical treatment with 0.02% CBS-211 A in aqueous vehicle significantly increased the conjunctival goblet cell density (P less than 0.01, impression cytology counting), stopped the evolution of the corneo-conjunctival surface alteration (P less than 0.05, rose bengal test), and restored a basically normal mucosecretory product quality in goblet cells (lectin histochemistry) compared to vehicle treatment. The results assess the efficacy of this compound in reversing KCS pathology in a relevant model different from general vitamin A deficiency models, and strongly support the rationale for using such a well-tolerated retinoid in dry eye treatment.
我们报告了合成视黄酸类似物CBS - 211 A对先前描述的兔干燥性角结膜炎（KCS）实验模型的影响。在水性载体中用0.02% CBS - 211 A进行为期9周的局部治疗，与载体治疗相比，显著增加了结膜杯状细胞密度（P小于0.01，印片细胞学计数），阻止了角膜结膜表面改变的进展（P小于0.05，孟加拉玫瑰红试验），并恢复了杯状细胞中基本正常的黏液分泌产物质量（凝集素组织化学）。结果评估了该化合物在不同于一般维生素A缺乏模型的相关模型中逆转KCS病理的疗效，并有力地支持了在干眼症治疗中使用这种耐受性良好的类视黄醇的理论依据。
