Gilbard J P, Rossi S R, Gray K L, Hanninen L A, Kenyon K R
Eye Research Institute, Boston, MA 02114.
Invest Ophthalmol Vis Sci. 1988 Mar;29(3):374-8.
We report the natural history of keratoconjunctivitis sicca (KCS) in two rabbit models. The first one (full KCS model) was created by closing the lacrimal gland excretory duct, and removing the nictitating membrane and harderian gland. We created the second one (lacrimal gland duct only [LGDO]-KCS model) by closing the lacrimal gland excretory duct. Although tear film osmolarity was abnormally high in both models, it was higher in the full KCS model. Decreases in corneal epithelial glycogen and in conjunctival goblet cell density, and morphological abnormalities of the conjunctiva correlated with increases in tear film osmolarity and duration of disease.
我们报告了两种兔模型中干燥性角结膜炎（KCS）的自然病程。第一种模型（完全KCS模型）通过封闭泪腺排泄管、切除瞬膜和哈德氏腺构建而成。第二种模型（仅泪腺导管[LGDO]-KCS模型）通过封闭泪腺排泄管构建而成。尽管两种模型的泪膜渗透压均异常升高，但完全KCS模型中的渗透压更高。角膜上皮糖原减少、结膜杯状细胞密度降低以及结膜形态异常与泪膜渗透压升高和疾病持续时间相关。
