非洲孕期疟疾的间歇性预防治疗：新进展与需求
Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed?
作者信息
Vallely Andrew, Vallely Lisa, Changalucha John, Greenwood Brian, Chandramohan Daniel
机构信息
National institute for Medical Research, Mwanza Centre, PO Box 1462, Mwanza, Tanzania.
出版信息
Malar J. 2007 Feb 16;6:16. doi: 10.1186/1475-2875-6-16.
Abstract
Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but increasing levels of parasite resistance mean that the benefits of national SP-IPT programmes may soon be seriously undermined in much of the region. Hence, there is an urgent need to develop alternative drug regimens for IPT in pregnancy. This paper reviews published safety and efficacy data on various antimalarials and proposes several candidate combination regimens for assessment in phase II/III clinical trials.
摘要
恶性疟是撒哈拉以南非洲高传播地区孕产妇、围产期和新生儿发病的重要原因。磺胺多辛-乙胺嘧啶间歇性预防治疗（SP-IPT）已被证明在减轻妊娠相关疟疾负担方面有效，但寄生虫耐药性水平不断上升意味着该地区许多国家的SP-IPT计划的益处可能很快会受到严重影响。因此，迫切需要开发用于孕期IPT的替代药物方案。本文综述了已发表的各种抗疟药的安全性和有效性数据，并提出了几种候选联合用药方案，以供在II/III期临床试验中进行评估。
相似文献
1
Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed?非洲孕期疟疾的间歇性预防治疗：新进展与需求
Malar J. 2007 Feb 16;6:16. doi: 10.1186/1475-2875-6-16.
2
Intermittent preventive treatment against malaria: an update.疟疾间歇性预防治疗：更新。
Expert Rev Anti Infect Ther. 2010 May;8(5):589-606. doi: 10.1586/eri.10.36.
3
Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda.乌干达西部孕期疟疾间歇性预防治疗无效与强效耐药性
Malar J. 2015 Sep 26;14:372. doi: 10.1186/s12936-015-0909-7.
4
Effectiveness of co-trimoxazole to prevent Plasmodium falciparum malaria in HIV-positive pregnant women in sub-Saharan Africa: an open-label, randomized controlled trial.复方新诺明预防撒哈拉以南非洲地区 HIV 阳性孕妇中恶性疟原虫疟疾的效果：一项开放标签、随机对照试验。
Clin Infect Dis. 2014 Mar;58(5):651-9. doi: 10.1093/cid/cit806. Epub 2013 Dec 12.
5
Intermittent preventive treatment of malaria in pregnancy: at the crossroads of public health policy.孕妇间歇性预防治疗疟疾：公共卫生政策的十字路口。
Trop Med Int Health. 2011 Jul;16(7):774-85. doi: 10.1111/j.1365-3156.2011.02765.x. Epub 2011 Apr 7.
6
Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy.阿奇霉素-氯喹与妊娠期疟疾的间歇预防性治疗
Malar J. 2008 Dec 16;7:255. doi: 10.1186/1475-2875-7-255.
7
Parasitological efficacy of antimalarials in the treatment and prevention of falciparum malaria in pregnancy 1998 to 2009: a systematic review.1998 年至 2009 年抗疟药物治疗和预防妊娠疟疾的寄生虫学疗效：系统评价。
BJOG. 2011 Jan;118(2):123-35. doi: 10.1111/j.1471-0528.2010.02810.x.
8
Intermittent preventive treatment of malaria in pregnancy: a community-based delivery system and its effect on parasitemia, anemia and low birth weight in Uganda.孕期疟疾的间歇性预防治疗：乌干达基于社区的实施系统及其对寄生虫血症、贫血和低出生体重的影响
Int J Infect Dis. 2008 Jan;12(1):22-9. doi: 10.1016/j.ijid.2006.10.008. Epub 2007 May 29.
9
Intermittent preventive therapy for malaria in pregnancy: is sulfadoxine-pyrimethamine the right drug?孕妇疟疾的间歇性预防治疗：磺胺多辛-乙胺嘧啶是正确的药物吗？
Clin Pharmacol Ther. 2010 Feb;87(2):160-2. doi: 10.1038/clpt.2009.284.
10
Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa.孕期疟疾预防与新生儿体重和死亡率的关系：非洲 32 个国家横断面数据集的荟萃分析
Lancet Infect Dis. 2012 Dec;12(12):942-9. doi: 10.1016/S1473-3099(12)70222-0. Epub 2012 Sep 18.
引用本文的文献
1
Congenital malaria in a neonate born in a malaria-endemic area: a case report.疟疾流行地区一名新生儿的先天性疟疾：病例报告
J Med Case Rep. 2025 Aug 31;19(1):434. doi: 10.1186/s13256-025-05525-3.
2
Efficacy and Safety of Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria in Pregnant Women: A Systematic Review and Meta-Analysis.基于青蒿素的联合疗法治疗孕妇非复杂性疟疾的疗效和安全性：一项系统评价和荟萃分析。
Ther Clin Risk Manag. 2021 Dec 22;17:1353-1370. doi: 10.2147/TCRM.S336771. eCollection 2021.
3
Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with uncomplicated malaria in Burkina Faso: an open label trial.青蒿琥酯和双氢青蒿素在布基纳法索未并发疟疾的孕妇和非孕妇中的群体药代动力学：一项开放标签试验。
Wellcome Open Res. 2019 Mar 7;4:45. doi: 10.12688/wellcomeopenres.14849.2. eCollection 2019.
4
Transmission dynamics of co-endemic Plasmodium vivax and P. falciparum in Ethiopia and prevalence of antimalarial resistant genotypes.埃塞俄比亚间日疟原虫和恶性疟原虫共流行的传播动态及抗疟基因型的流行情况
PLoS Negl Trop Dis. 2017 Jul 26;11(7):e0005806. doi: 10.1371/journal.pntd.0005806. eCollection 2017 Jul.
5
Burden of Placental Malaria among Pregnant Women Who Use or Do Not Use Intermittent Preventive Treatment at Mulago Hospital, Kampala.坎帕拉穆拉戈医院使用或未使用间歇性预防治疗的孕妇中胎盘疟疾的负担
Malar Res Treat. 2016;2016:1839795. doi: 10.1155/2016/1839795. Epub 2016 Dec 13.
6
Trimester-Specific Population Pharmacokinetics and Other Correlates of Variability in Sulphadoxine-Pyrimethamine Disposition Among Ugandan Pregnant Women.乌干达孕妇中不同孕期周数的周效磺胺-乙胺嘧啶处置的群体药代动力学及其他变异相关因素
Drugs R D. 2015 Dec;15(4):351-62. doi: 10.1007/s40268-015-0110-z.
7
Plasmodium falciparum parasitaemia among booked parturients who received two doses of sulfadoxine-pyrimethamine (SP) for intermittent preventive treatment in pregnancy (IPTp) in a tertiary health facility Southeast Nigeria.在尼日利亚东南部一家三级医疗机构中，接受两剂周效磺胺-乙胺嘧啶（SP）进行孕期间歇性预防治疗（IPTp）的已登记产妇中的恶性疟原虫血症情况。
Niger Med J. 2015 May-Jun;56(3):218-24. doi: 10.4103/0300-1652.160406.
8
Intermittent use of sulphadoxine-pyrimethamine for malaria prevention: a cross-sectional study of knowledge and practices among Ugandan women attending an urban antenatal clinic.间歇性使用周效磺胺-乙胺嘧啶预防疟疾：一项针对乌干达城市产前诊所就诊女性的知识与实践的横断面研究。
Malar J. 2014 Oct 11;13:399. doi: 10.1186/1475-2875-13-399.
9
Health facility-based data on women receiving sulphadoxine-pyrimethamine during pregnancy in Tanzania: lessons to learn from a cross-sectional survey in Mkuranga and Mufindi districts and other national survey reports.坦桑尼亚基于卫生机构的孕妇接受磺胺多辛-乙胺嘧啶数据：姆库兰加和穆芬迪地区的横断面调查及其他国家调查报告中吸取的经验教训。
Reprod Health. 2014 Jan 16;11(1):6. doi: 10.1186/1742-4755-11-6.
10
Psychosocial, behavioural and health system barriers to delivery and uptake of intermittent preventive treatment of malaria in pregnancy in Tanzania - viewpoints of service providers in Mkuranga and Mufindi districts.坦桑尼亚孕期疟疾间歇性预防治疗的提供与采用过程中的社会心理、行为及卫生系统障碍——姆库兰加和穆芬迪地区服务提供者的观点
BMC Health Serv Res. 2014 Jan 13;14:15. doi: 10.1186/1472-6963-14-15.
本文引用的文献
1
Antimalarial drugs in pregnancy: a review.孕期抗疟药物：综述
Curr Drug Saf. 2006 Jan;1(1):1-15. doi: 10.2174/157488606775252584.
2
Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial.阿莫地喹联合磺胺多辛-乙胺嘧啶单独或联合用于孕期疟疾治疗的疗效、安全性及耐受性：一项随机试验
Lancet. 2006 Oct 14;368(9544):1349-56. doi: 10.1016/S0140-6736(06)69559-7.
3
Targeting of hematin by the antimalarial pyronaridine.抗疟药咯萘啶对血红素的靶向作用。
Antimicrob Agents Chemother. 2006 Jun;50(6):2197-200. doi: 10.1128/AAC.00119-06.
4
Prevention of malaria during pregnancy in West Africa: policy change and the power of subregional action.西非孕期疟疾预防：政策变化与次区域行动的力量
Trop Med Int Health. 2006 Apr;11(4):462-9. doi: 10.1111/j.1365-3156.2006.01593.x.
5
Reaching the Abuja target for intermittent preventive treatment of malaria in pregnancy in African women: a review of progress and operational challenges.实现非洲妇女孕期疟疾间歇性预防治疗的阿布贾目标：进展与操作挑战综述
Trop Med Int Health. 2006 Apr;11(4):409-18. doi: 10.1111/j.1365-3156.2006.01585.x.
6
Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.口服青蒿琥酯治疗妊娠合并急性非复杂性恶性疟患者后双氢青蒿素的药代动力学
Eur J Clin Pharmacol. 2006 May;62(5):367-71. doi: 10.1007/s00228-006-0118-y. Epub 2006 Mar 22.
7
Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial.青蒿琥酯与磺胺多辛-乙胺嘧啶季节性间歇预防性治疗对塞内加尔儿童疟疾的预防作用：一项随机、安慰剂对照、双盲试验
Lancet. 2006 Feb 25;367(9511):659-67. doi: 10.1016/S0140-6736(06)68264-0.
8
Challenges in the concurrent management of malaria and HIV in pregnancy in sub-Saharan Africa.撒哈拉以南非洲地区孕期疟疾与艾滋病并发管理面临的挑战。
Lancet Infect Dis. 2006 Feb;6(2):100-11. doi: 10.1016/S1473-3099(06)70383-8.
9
Artesunate plus sulfadoxine-pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria during pregnancy in eastern Sudan.青蒿琥酯联合磺胺多辛-乙胺嘧啶治疗苏丹东部妊娠期非复杂性恶性疟
Trans R Soc Trop Med Hyg. 2006 Jul;100(7):632-5. doi: 10.1016/j.trstmh.2005.09.019. Epub 2006 Jan 24.
10
A randomized trial comparing the efficacy of four treatment regimens for uncomplicated falciparum malaria in Assam state, India.一项比较印度阿萨姆邦四种治疗方案对单纯性恶性疟疗效的随机试验。
Trans R Soc Trop Med Hyg. 2006 Feb;100(2):108-18. doi: 10.1016/j.trstmh.2005.06.016. Epub 2005 Nov 14.
Zotero 插件