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非洲孕期疟疾的间歇性预防治疗：新进展与需求

Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed?

作者信息

Vallely Andrew, Vallely Lisa, Changalucha John, Greenwood Brian, Chandramohan Daniel

机构信息

National institute for Medical Research, Mwanza Centre, PO Box 1462, Mwanza, Tanzania.

出版信息

Malar J. 2007 Feb 16;6:16. doi: 10.1186/1475-2875-6-16.

DOI:10.1186/1475-2875-6-16
PMID:17306014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1805504/
Abstract

Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but increasing levels of parasite resistance mean that the benefits of national SP-IPT programmes may soon be seriously undermined in much of the region. Hence, there is an urgent need to develop alternative drug regimens for IPT in pregnancy. This paper reviews published safety and efficacy data on various antimalarials and proposes several candidate combination regimens for assessment in phase II/III clinical trials.

摘要

恶性疟是撒哈拉以南非洲高传播地区孕产妇、围产期和新生儿发病的重要原因。磺胺多辛-乙胺嘧啶间歇性预防治疗（SP-IPT）已被证明在减轻妊娠相关疟疾负担方面有效，但寄生虫耐药性水平不断上升意味着该地区许多国家的SP-IPT计划的益处可能很快会受到严重影响。因此，迫切需要开发用于孕期IPT的替代药物方案。本文综述了已发表的各种抗疟药的安全性和有效性数据，并提出了几种候选联合用药方案，以供在II/III期临床试验中进行评估。

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Antimalarial drugs in pregnancy: a review.孕期抗疟药物：综述
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Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.口服青蒿琥酯治疗妊娠合并急性非复杂性恶性疟患者后双氢青蒿素的药代动力学
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Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial.青蒿琥酯与磺胺多辛-乙胺嘧啶季节性间歇预防性治疗对塞内加尔儿童疟疾的预防作用：一项随机、安慰剂对照、双盲试验
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