Department of Urology, E-DA Hospital/I-SHOU University, Kaohsiung, Taiwan, ROC.
Oncol Rep. 2012 Apr;27(4):1193-9. doi: 10.3892/or.2011.1610. Epub 2011 Dec 22.
The aim of this study was to calculate the positive predictive value (PPV) and negative predictive value (NPV) to determine whether p53 codon 72 can be used as a bladder cancer management index. Ninety-six patients diagnosed with bladed cancer and two control groups of 427 randomly sampled community participants and 142 non-cancerous individuals without a prior history of cancer were enrolled. After preliminary analysis, the convergent validity resulted in 96 patients from this study and 129 patients from our previous study. Results showed that these two groups were of the same population, and could be merged into one case group. Logistic regression showed that the Pro/Pro genotype was not statistically significantly associated with bladder cancer incidence using each sample set after adjustment by age and gender. Moreover, the Pro/Pro genotype was not associated with high-grade tumors (P=0.078), but was highly correlated to muscle-invasive tumors (P=0.002). Pro/Pro genotype carriers were estimated to have a 3.36-fold higher risk to develop invasive tumors compared to non-carriers. The NPV of the Pro/Pro genotype for invasive tumors was 88.00%, and the PPV was 31.91%. By Cox regression analysis, high-grade tumors were associated with recurrence (P=0.020, OR=1.83), whereas invasive tumors were associated with cancer-related death (P<0.001, OR=2.87). p53 codon 72 polymorphism is associated with bladder cancer progression rather than incidence and prognosis. The Pro/Pro genotype in p53 codon 72 polymorphism shows a high NPV for bladder cancer progression, thus, it can be used clinically as a progression index in bladder cancer management.
本研究旨在计算阳性预测值（PPV）和阴性预测值（NPV），以确定 p53 密码子 72 是否可用作膀胱癌管理指标。共纳入 96 例膀胱癌患者和 2 个对照组（427 名随机抽取的社区参与者和 142 名无癌症病史的非癌症个体）。经过初步分析，本研究的 96 例患者和之前研究的 129 例患者具有收敛效度。结果表明，这两组人群相同，可以合并为一个病例组。逻辑回归显示，在调整年龄和性别后，每个样本组的 Pro/Pro 基因型与膀胱癌的发生均无统计学相关性。此外，Pro/Pro 基因型与高级别肿瘤无关（P=0.078），但与肌层浸润性肿瘤高度相关（P=0.002）。与非携带者相比，Pro/Pro 基因型携带者发生浸润性肿瘤的风险估计增加了 3.36 倍。Pro/Pro 基因型对浸润性肿瘤的 NPV 为 88.00%，PPV 为 31.91%。通过 Cox 回归分析，高级别肿瘤与复发相关（P=0.020，OR=1.83），而浸润性肿瘤与癌症相关死亡相关（P<0.001，OR=2.87）。p53 密码子 72 多态性与膀胱癌进展而非发病和预后相关。p53 密码子 72 多态性中的 Pro/Pro 基因型对膀胱癌进展具有较高的 NPV，因此，可在临床上将其用作膀胱癌管理中的进展指标。
