Pennell Craig E, Jacobsson Bo, Williams Scott M, Buus Rebecca M, Muglia Louis J, Dolan Siobhan M, Morken Nils-Halvdan, Ozcelik Hilmi, Lye Stephen J, Relton Caroline
School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia.
Am J Obstet Gynecol. 2007 Feb;196(2):107-18. doi: 10.1016/j.ajog.2006.03.109.
Over the last decade, it has become increasingly apparent that the cause of preterm birth is multifactorial, involving both genetic and environmental factors. With the development of new technologies capable of probing the genome, exciting possibilities now present themselves to gain new insight into the mechanisms leading to preterm birth. This review aims to develop research guidelines for the conduct of genetic epidemiology studies of preterm birth with the expectation that this will ultimately facilitate the comparison of data sets between study cohorts, both nationally and internationally. Specifically, the 4 areas addressed in this review includes: (1) phenotypic criteria, (2) study design, (3) considerations in the selection of control populations, and (4) candidate gene selection. This article is the product of discussions initiated by the authors at the 3rd International Workshop on Biomarkers and Preterm Birth held at the University of California, Los Angeles, Los Angeles, CA, in March 2005.
在过去十年中，越来越明显的是，早产的原因是多因素的，涉及遗传和环境因素。随着能够探测基因组的新技术的发展，现在出现了令人兴奋的可能性，以获得对导致早产机制的新见解。本综述旨在制定早产遗传流行病学研究的指导方针，期望这最终将促进国内和国际研究队列之间数据集的比较。具体而言，本综述涉及的四个领域包括：（1）表型标准，（2）研究设计，（3）对照人群选择的考虑因素，以及（4）候选基因选择。本文是作者在2005年3月于加利福尼亚州洛杉矶市加利福尼亚大学洛杉矶分校举行的第三届生物标志物与早产国际研讨会上发起的讨论成果。
