Kriegs Jan Ole, Churakov Gennady, Jurka Jerzy, Brosius Jürgen, Schmitz Jürgen
Institute of Experimental Pathology, ZMBE, University of Münster, Von-Esmarch-Str. 56, D-48149 Münster, Germany.
Trends Genet. 2007 Apr;23(4):158-61. doi: 10.1016/j.tig.2007.02.002. Epub 2007 Feb 20.
The evolutionary relationships of 7SL RNA-derived SINEs such as the primate Alu or the rodent B1 elements have hitherto been obscure. We established an unambiguous phylogenetic tree for Supraprimates, and derived intraordinal relationships of the 7SL RNA-derived SINEs. As well as new elements in Tupaia and primates, we also found that the purported ancestral fossil Alu monomer was restricted to Primates, and provide here the first description of a potential chimeric promoter box region in SINEs.
迄今为止，灵长类动物的Alu或啮齿动物的B1元件等7SL RNA衍生的短散在重复元件（SINEs）的进化关系一直不明。我们构建了一个明确的超灵长类系统发育树，并推导了7SL RNA衍生的SINEs的目内关系。除了树鼩和灵长类动物中的新元件，我们还发现所谓的祖先化石Alu单体仅限于灵长类动物，并在此首次描述了SINEs中一个潜在的嵌合启动子盒区域。
