Harrison Ben J, Yücel Murat, Pujol Jesus, Pantelis Christos
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia.
Schizophr Res. 2007 Mar;91(1-3):82-6. doi: 10.1016/j.schres.2006.12.027. Epub 2007 Feb 16.
Task-induced deactivations (TIDs) of midline cortical regions are readily observed in fMRI studies and may reflect elements of a 'default-mode' of brain function associated with self-directed mental processes at rest. In this study, we examined this TID phenomenon in schizophrenia and its relevance to patients' symptoms, task performance and level of emotional awareness. Relative to control subjects, patients showed significantly greater TID of the rostral anterior cingulate (rAC)/medial prefrontal cortex (mPFC) and precuneus (PrC)/posterior cingulate cortex (PC). The magnitude of prefrontal TIDs was associated with patients' task performance and emotional awareness for others. The nature of these associations suggests a complex interchange between cognitive and emotional influences on the resting-state activity of these prefrontal 'default mode' regions in schizophrenia.
在功能磁共振成像（fMRI）研究中很容易观察到中线皮质区域的任务诱导失活（TID），这可能反映了与静息时自我导向心理过程相关的大脑功能“默认模式”的要素。在本研究中，我们研究了精神分裂症中的这种TID现象及其与患者症状、任务表现和情绪意识水平的相关性。相对于对照受试者，患者在喙部前扣带回（rAC）/内侧前额叶皮质（mPFC）以及楔前叶（PrC）/后扣带回皮质（PC）表现出明显更强的TID。前额叶TID的程度与患者的任务表现以及对他人的情绪意识相关。这些关联的性质表明，在精神分裂症中，认知和情绪对这些前额叶“默认模式”区域静息状态活动的影响之间存在复杂的相互作用。
