Park Il Ho, Park Hae-Jeong, Chun Ji-Won, Kim Eung Yeop, Kim Jae-Jin
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea.
Neurosci Lett. 2008 Aug 1;440(2):119-24. doi: 10.1016/j.neulet.2008.05.094. Epub 2008 Jun 16.
Patients with schizophrenia have impairment in cognitive-emotional interaction that is reflected in delusion formation and poor social functioning. Although monitoring deficits in the anterior cingulate have been observed in schizophrenia, the involvement of the affective division of the anterior cingulate implicated in cognitive modulation of emotional processing has not been directly addressed in schizophrenia. In this study, we examined the function of the affective division of the anterior cingulate and the related neural systems by using a modified emotional Stroop fMRI paradigm. Fourteen patients with schizophrenia and fourteen healthy controls performed an emotional appraisal task with semantically relevant emotional interferences during fMRI scanning. The patients with schizophrenia were significantly less efficient than the healthy controls during the emotional incongruence trials. When emotionally incongruent trials were compared to congruent trials, relative deactivations of the subgenual cingulate gyrus and the ventromedial prefrontal cortex observed in the healthy controls were not found in the patient group and activities of these regions inversely correlated with emotional interference to performance efficiency and response accuracy respectively in the patient group. In addition, relative activation in the dorsolateral prefrontal cortex was observed only in the patient group. These findings suggest that deficit in cognitive modulation over emotional interference in patients with schizophrenia may be explained by failure in suppressing the affective division of the anterior cingulate despite attentional effort. This may provide evidence for the failure in suppressing the bottom-up processing of emotion during cognitive-emotional interaction in schizophrenia.
精神分裂症患者在认知 - 情感交互方面存在障碍，这体现在妄想形成和社交功能不佳上。尽管在精神分裂症患者中已观察到前扣带回的监测缺陷，但前扣带回情感分区在情感加工认知调节中的作用在精神分裂症中尚未得到直接研究。在本研究中，我们使用改良的情绪Stroop功能磁共振成像范式来研究前扣带回情感分区及相关神经系统的功能。14名精神分裂症患者和14名健康对照在功能磁共振成像扫描期间执行一项带有语义相关情绪干扰的情绪评估任务。在情绪不一致试验中，精神分裂症患者的效率显著低于健康对照。当将情绪不一致试验与一致试验进行比较时，在健康对照中观察到的膝下扣带回和腹内侧前额叶皮质的相对失活在患者组中未发现，并且在患者组中这些区域的活动分别与对表现效率和反应准确性的情绪干扰呈负相关。此外，仅在患者组中观察到背外侧前额叶皮质的相对激活。这些发现表明，精神分裂症患者对情绪干扰的认知调节缺陷可能是由于尽管付出了注意力努力，但仍无法抑制前扣带回情感分区所致。这可能为精神分裂症患者在认知 - 情感交互过程中无法抑制自下而上的情绪加工提供证据。
