Jáni Martin, Kikinis Zora, Lošák Jan, Pasternak Ofer, Szczepankiewicz Filip, Heller Carina, Swago Sophia, Silva Annelise, Bouix Sylvain, Kubicki Marek, Ustohal Libor, Kudlička Petr, Vojtíšek Lubomír, Westin Carl-Frederik, Kašpárek Tomáš
Department of Psychiatry, Faculty of Medicine, Masaryk University and University Hospital Brno, Brno, Czechia.
Central European Institute of Technology, Masaryk University, Brno, Czechia.
Front Psychiatry. 2021 Apr 1;12:601742. doi: 10.3389/fpsyt.2021.601742. eCollection 2021.
We assessed the relationship between emotional awareness (e.g., the ability to identify and differentiate our own feelings and feelings of others) and regional brain volumes in healthy and in schizophrenia groups. Magnetic resonance images of 29 subjects with schizophrenia and 33 matched healthy controls were acquired. Brain gray matter was parcellated using FreeSurfer and 28 regions of interest associated with emotional awareness were analyzed. All participants were assessed using the Levels of Emotional Awareness Scale (LEAS) of Self and of Other. LEAS scores were correlated with gray matter volume for each hemisphere on the 14 brain regions of the emotional awareness network. Individuals with schizophrenia showed decreased emotional awareness on both LEAS Self and LEAS Other compared to healthy controls. There were no statistically significant between-group differences in gray matter volumes of the emotional awareness network. The performance on LEAS Other correlated negatively with right precuneus gray matter volume only in the schizophrenia group. Our findings suggest a relationship between gray matter volume of the right precuneus and deficits in understanding of emotional states of others in schizophrenia.
我们评估了健康人群和精神分裂症患者群体中情绪意识（例如，识别和区分自身感受以及他人感受的能力）与脑区体积之间的关系。获取了29名精神分裂症患者和33名匹配的健康对照者的磁共振图像。使用FreeSurfer对脑灰质进行分割，并分析了与情绪意识相关的28个感兴趣区域。所有参与者均使用自我和他人情绪意识量表（LEAS）进行评估。LEAS得分与情绪意识网络14个脑区中每个半球的灰质体积相关。与健康对照者相比，精神分裂症患者在LEAS自我和LEAS他人方面均表现出情绪意识下降。情绪意识网络的灰质体积在组间无统计学显著差异。仅在精神分裂症组中，LEAS他人方面的表现与右侧楔前叶灰质体积呈负相关。我们的研究结果表明，右侧楔前叶灰质体积与精神分裂症患者理解他人情绪状态的缺陷之间存在关联。
