Grapin-Botton Anne, Constam Daniel
ISREC and Ecole Polytechnique Fédérale de Lausanne, Chemin des Boveresses 155, Case Postale, CH-1066 Epalinges s/Lausanne, Switzerland.
Mech Dev. 2007 Apr;124(4):253-78. doi: 10.1016/j.mod.2007.01.001. Epub 2007 Jan 11.
Endoderm differentiation and movements are of fundamental importance not only for subsequent morphogenesis of the digestive tract but also to enable normal patterning and differentiation of mesoderm- and ectoderm-derived organs. This review defines the tissues that have been called endoderm in different species, their cellular origin and their movements. We take a comparative approach to ask how signaling pathways leading to embryonic and extraembryonic endoderm differentiation have emerged in different organisms, how they became integrated and point to specific gaps in our knowledge that would be worth filling. Lastly, we address whether the gastrulation movements that lead to endoderm internalization are coupled with its differentiation.
内胚层的分化和迁移不仅对消化道随后的形态发生至关重要，而且对于中胚层和外胚层来源器官的正常模式形成和分化也至关重要。本综述定义了在不同物种中被称为内胚层的组织、它们的细胞起源及其迁移。我们采用比较方法来探讨导致胚胎和胚外内胚层分化的信号通路是如何在不同生物体中出现的、它们是如何整合的，并指出我们知识中值得填补的特定空白。最后，我们探讨导致内胚层内化的原肠胚形成运动是否与其分化相关联。
