Cleaver O, Krieg P A
Department of Molecular and Cellular Biology, Harvard University, Sherman Fairchild Biochemistry Building, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.
Dev Biol. 2001 Jun 1;234(1):1-12. doi: 10.1006/dbio.2001.0214.
Endodermally derived organs of the gastrointestinal and respiratory system form at distinct anterioposterior and dorsoventral locations along the vertebrate body axis. This stereotyped program of organ formation depends on the correct patterning of the endodermal epithelium so that organ differentiation and morphogenesis occur at appropriate positions along the gut tube. Whereas some initial patterning of the endoderm is known to occur early, during germ-layer formation and gastrulation, later signaling events, originating from a number of adjacent tissue layers, are essential for the development of endodermal organs. Previous studies have shown that signals arising from the notochord are important for patterning of the ectodermally derived floor plate of the neural tube and the mesodermally derived somites. This review will discuss recent evidence indicating that signals arising from the notochord also play a role in regulating endoderm development.
胃肠道和呼吸系统的内胚层衍生器官沿着脊椎动物的体轴在不同的前后和背腹位置形成。这种器官形成的定型程序取决于内胚层上皮的正确模式，以便器官分化和形态发生在肠管的适当位置发生。虽然已知内胚层的一些初始模式在早期发生，即在胚层形成和原肠胚形成期间，但来自许多相邻组织层的后期信号事件对于内胚层器官的发育至关重要。先前的研究表明，来自脊索的信号对于神经管外胚层衍生的底板和中胚层衍生的体节的模式形成很重要。这篇综述将讨论最近的证据，表明来自脊索的信号在调节内胚层发育中也起作用。
