Le M T Q, Jamrozik K, Davis T M E, Norman P E
School of Surgery and Pathology, The University of Western Australia, Nedlands, Western Australia, Australia.
Eur J Vasc Endovasc Surg. 2007 May;33(5):599-604. doi: 10.1016/j.ejvs.2006.12.017. Epub 2007 Feb 16.
There is evidence of a negative association between diabetes and abdominal aortic aneurysm (AAA). The aim of this study was to assess whether there is a similar relationship between both diabetes and glucose level, and infra-renal aortic diameter throughout its range.
Infra-renal aortic diameter was measured using ultrasound in 12,203 men aged 65-83 years as part of a trial of screening for AAA. A range of cardiovascular risk factors were also assessed. In a follow-up study, fasting serum glucose was measured in 2,859 non-diabetic men. Aortic diameter was logarithmically transformed and treated as both a continuous and categorical variable in stepwise multivariate linear and logistic models.
The median aortic diameter was slightly smaller in the diabetic men (21.3+/-3.9 vs 21.6+/-3.8, P<0.0001). There was an independent negative association between diabetes and AAA (OR 0.79, 95% CI: 0.63,0.98), and an inverse correlation (Coefficient: -0.0064, p=0.0024) between fasting glucose and aortic diameter in non-diabetic men.
Diabetes is inversely associated with both AAA and aortic diameter in men over 65 years. This association is independent of other risk factors for AAA. Aortic diameter also has an inverse relationship with fasting glucose concentrations in men without diabetes.
有证据表明糖尿病与腹主动脉瘤（AAA）之间存在负相关。本研究的目的是评估糖尿病和血糖水平与整个范围内的肾下腹主动脉直径之间是否存在类似关系。
作为AAA筛查试验的一部分，对12203名65 - 83岁男性使用超声测量肾下腹主动脉直径。还评估了一系列心血管危险因素。在一项随访研究中，对2859名非糖尿病男性测量空腹血清葡萄糖。在逐步多元线性和逻辑模型中，将主动脉直径进行对数转换，并将其作为连续变量和分类变量进行处理。
糖尿病男性的主动脉直径中位数略小（21.3±3.9对21.6±3.8，P<0.0001）。糖尿病与AAA之间存在独立的负相关（OR 0.79，95%CI：0.63，0.98），非糖尿病男性的空腹血糖与主动脉直径之间存在负相关（系数：-0.0064，p = 0.0024）。
在65岁以上男性中，糖尿病与AAA和主动脉直径均呈负相关。这种关联独立于AAA的其他危险因素。在无糖尿病男性中，主动脉直径与空腹血糖浓度也呈负相关。
