Gangaram-Panday Shanti T, Faas Marijke M, de Vos Paul
Transplantation Biology and Immunoendocrinology, Section of Medical Biology, Department of Pathology and Laboratory Medicine, University Medical Centre Groningen, Groningen, The Netherlands.
Trends Mol Med. 2007 Apr;13(4):164-73. doi: 10.1016/j.molmed.2007.02.002. Epub 2007 Feb 20.
Many approaches of stem-cell therapy for the treatment of diabetes have been described. One is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell transplantation. During recent years three types of stem cells have been investigated: embryonic stem cells, bone-marrow-derived stem cells and organ-bound stem cells. We discuss the advantages and limitations of these different cell types. The applicability for the treatment of dysfunction of beta cells in the pancreas has been demonstrated for all three cell types, but more-detailed understanding of the sequence of events during differentiation is required to produce fully functional insulin-producing cells.
已经描述了许多用于治疗糖尿病的干细胞疗法。一种是应用干细胞替代天然内源性胰腺中无功能的胰岛细胞；另一种是将干细胞用作胰岛细胞移植的不竭来源。近年来，已经研究了三种类型的干细胞：胚胎干细胞、骨髓来源的干细胞和器官结合干细胞。我们讨论了这些不同细胞类型的优缺点。所有这三种细胞类型都已证明可用于治疗胰腺中β细胞功能障碍，但需要更详细地了解分化过程中的事件顺序，以产生功能完全正常的胰岛素产生细胞。
