Carter B Christian, Plager David A, Neely Daniel E, Sprunger Derek T, Sondhi Naval, Roberts Gavin J
Indiana University Medical Center, 702 Rotary Circle, Indianapolis, IN 46202, USA.
J AAPOS. 2007 Feb;11(1):34-40. doi: 10.1016/j.jaapos.2006.08.015. Epub 2006 Nov 2.
Endoscopic cyclophotocoagulation (ECP) has been shown to be a useful adjunct in the management of a variety of difficult pediatric and adult glaucomas. This study reports the efficacy and safety of this procedure for pediatric aphakic and pseudophakic glaucoma.
ECP was performed on 34 eyes of 25 patients under 16 years of age with aphakic or pseudophakic glaucoma between April 1994 and November 2004. Patients were followed for a minimum of 12 months or until a treatment failure had been declared. Treatment failure was defined as postoperative intraocular pressure (IOP) of >24 mm Hg and IOP lowering of less than 15% despite the addition of glaucoma medications or the occurrence of any visually significant complications. Aphakic eyes of patients with congenital glaucoma or an anterior segment dysgenesis were not included in the study group.
Pretreatment IOP averaged 32.6 mm Hg in the 34 eyes, compared with a final postoperative average of 22.9 mm Hg. Mean follow-up period for study eyes was 44.4 months, and the average number of procedures per eye was 1.5. Overall success rate was 53% (18/34). Thirteen of the 34 eyes (38%) received one treatment only and were deemed a success. Retinal detachments developed in two eyes within the first postoperative month.
ECP is a useful tool in the treatment of aphakic and pseudophakic glaucoma, with a low rate of visually significant complications. Retreatment of eyes improved the overall success rate, although experience with cases beyond two treatment sessions is limited. Hypotony was not encountered despite 8 of the 34 eyes receiving 360 degrees of total endocyclophotoablation to the ciliary processes.
内镜睫状体光凝术(ECP)已被证明是治疗各种难治性小儿和成人青光眼的一种有用辅助方法。本研究报告了该手术治疗小儿无晶状体和人工晶状体性青光眼的疗效和安全性。
1994年4月至2004年11月期间,对25例16岁以下患有无晶状体或人工晶状体性青光眼的患者的34只眼睛进行了ECP。患者至少随访12个月或直至宣布治疗失败。治疗失败定义为术后眼压(IOP)>24 mmHg,尽管加用了青光眼药物但眼压降低小于15%,或发生任何具有视觉意义的并发症。先天性青光眼或前段发育异常患者的无晶状体眼未纳入研究组。
34只眼睛术前平均眼压为32.6 mmHg,术后最终平均眼压为22.9 mmHg。研究眼的平均随访期为44.4个月,每只眼睛的平均手术次数为1.5次。总体成功率为53%(18/34)。34只眼睛中有13只(38%)仅接受了一次治疗并被视为成功。术后第一个月内有两只眼睛发生了视网膜脱离。
ECP是治疗无晶状体和人工晶状体性青光眼的一种有用工具,具有视觉意义的并发症发生率低。再次治疗可提高总体成功率,尽管超过两次治疗的病例经验有限。尽管34只眼睛中有8只对睫状突进行了360度全内镜睫状体光凝术,但未出现低眼压。