Sansonetti Philippe J, Di Santo James P
Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris, Cedex 15, France.
Immunity. 2007 Feb;26(2):149-61. doi: 10.1016/j.immuni.2007.02.004.
Beyond the innate response that is elicited when tissues are infected, bacterial pathogens have evolved strategies to subvert the immune response and "recalibrate" it both qualitatively and quantitatively, thereby achieving a balance consistent with the survival of both the microbe and its infected host, a compromise that is likely the result of a long process of coevolution between pathogens and their hosts. By collaboratively studying the mechanisms employed, microbiologists and immunologists are fostering development of a renewed approach of infectious diseases that is expected to provide useful new concepts and applications for their control. In addition, the molecular strategies developed by bacteria to dampen immune mechanisms result from such strong and prolonged selective pressure for survival that they may point to original mechanisms and targets to conceive novel immunomodulatory, anti-inflammatory, and anti-infectious molecules.
除了在组织受到感染时引发的固有反应外，细菌病原体还进化出了一些策略来颠覆免疫反应，并在质量和数量上对其进行“重新校准”，从而实现一种与微生物及其受感染宿主的生存相一致的平衡，这种折衷很可能是病原体与其宿主之间长期共同进化过程的结果。通过共同研究所采用的机制，微生物学家和免疫学家正在推动一种新的传染病研究方法的发展，预计这种方法将为传染病的控制提供有用的新概念和应用。此外，细菌为抑制免疫机制而开发的分子策略是由如此强大和持久的生存选择压力导致的，它们可能指向构思新型免疫调节、抗炎和抗感染分子的原始机制和靶点。
