Wood R A, Mudd K E, Eggleston P A
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md.
J Allergy Clin Immunol. 1992 Jan;89(1 Pt 1):126-30. doi: 10.1016/s0091-6749(05)80049-1.
This study was undertaken to determine the distribution of cat and dust mite allergens on wall surfaces and to assess the value of wall-wipe samples as a measure of allergen exposure. Paired samples were collected from 31 homes, 20 homes with cats and 11 homes without, by vacuuming 1 m2 of carpet and by wiping 1 square foot of an adjacent wall. Felis domesticus allergen I (Fel d I) was detected in 30 of 31 settled dust samples (range, not detectable to 832,000 mU/gm; median, 10,250 mU/gm) and in 27 of 31 wall-wipe samples (range, not detectable to 113.7 mU per filter; median, 1.2 mU per filter). There was a significant correlation between Fel d I content in settled dust and wall-wipe samples (rs = 0.73; p less than 0.001). To assess the reproducibility of the wall-wipe method, multiple wipe samples were obtained from 20 homes, revealing a mean coefficient of variation of 110%. In contrast to Fel d I, although Dermatophagoides farinae allergen I was detected in 23 of 25 settled dust samples (range, not detectable to 11,888 ng/gm; median, 1178 ng/gm), it was detected in only four of 25 wall-wipe samples. We conclude that cat allergen, but not dust mite allergen, is widely distributed on wall surfaces and that wipe samples provide a simple and effective means of assessing household exposure to cat allergen.
本研究旨在确定猫和尘螨过敏原在墙壁表面的分布情况，并评估擦拭墙壁样本作为过敏原暴露量度的价值。从31户家庭中采集了配对样本，其中20户养猫，11户未养猫，通过用吸尘器清洁1平方米的地毯以及擦拭相邻墙壁的1平方英尺来采集样本。在31份沉降灰尘样本中的30份（范围：未检测到至832,000 mU/gm；中位数：10,250 mU/gm）以及31份墙壁擦拭样本中的27份（范围：未检测到至每过滤器113.7 mU；中位数：每过滤器1.2 mU）中检测到猫过敏原I（Felis domesticus allergen I，Fel d I）。沉降灰尘和墙壁擦拭样本中的Fel d I含量之间存在显著相关性（rs = 0.73；p < 0.001）。为评估墙壁擦拭方法的可重复性，从20户家庭中获取了多个擦拭样本，结果显示平均变异系数为110%。与Fel d I不同，尽管在25份沉降灰尘样本中的23份（范围：未检测到至11,888 ng/gm；中位数：1178 ng/gm）中检测到了粉尘螨过敏原I（Dermatophagoides farinae allergen I），但在25份墙壁擦拭样本中仅在4份中检测到。我们得出结论，猫过敏原而非尘螨过敏原广泛分布于墙壁表面，并且擦拭样本提供了一种简单有效的评估家庭接触猫过敏原的方法。
