有机催化不对称合成5-羟基异恶唑烷：一条合成β-氨基酸的高对映选择性路线。
Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: a highly enantioselective route to beta-amino acids.
作者信息
Ibrahem Ismail, Rios Ramon, Vesely Jan, Zhao Gui-Ling, Córdova Armando
机构信息
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm, Sweden.
出版信息
Chem Commun (Camb). 2007 Feb 28(8):849-51. doi: 10.1039/b613410f. Epub 2006 Nov 23.
DOI:10.1039/b613410f
PMID:17308652
Abstract
The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and alpha,beta-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and beta-amino acids in high yields and with 90-99% ee.
摘要
本文介绍了N-保护羟基胺与α,β-不饱和醛之间的高度化学选择性和对映选择性有机催化串联反应；该反应能够以高产率和90-99%的对映体过量获得5-羟基异恶唑烷和β-氨基酸。
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