Mirón-López Gumersindo, Herrera-Ruiz Maribel, Estrada-Soto Samuel, Aguirre-Crespo Francisco, Vazquez-Navarrete Lorena, León-Rivera Ismael
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México.
J Nat Prod. 2007 Apr;70(4):557-62. doi: 10.1021/np0604634. Epub 2007 Feb 20.
Seven new tetrasaccharide glycosides, tyrianthins 1-7 (1-7), along with six known glycolipids were isolated from the roots of Ipomoea tyrianthina, and their structures were elucidated by spectroscopic and chemical methods. The content of resin glycosides in samples collected in three different regions was analyzed and compared, and the results showed that the flowering or dry season did not have any effect on the chemical composition for the same locality, but the growing location itself did affect the chemical composition of resin glycosides. Intraperitoneal administration to mice of tyrianthin 6 (6) resulted in antidepressant activity. Tyrianthin 6 (6), scammonin 1 (8), and scammonin 2 (9) exhibited dose-dependent protective effects against pentylenetetrazole-induced seizures. Also, tyrianthin 6 (6) and scammonin 2 (9) produced relaxant effects on spontaneous contractions in the isolated rat ileum.
从紫牵牛的根部分离出了七种新的四糖糖苷，即紫牵牛素1 - 7（1 - 7），以及六种已知的糖脂，并通过光谱和化学方法阐明了它们的结构。分析并比较了在三个不同地区采集的样本中树脂糖苷的含量，结果表明，对于同一地点，开花期或干燥季节对化学成分没有任何影响，但生长地点本身确实会影响树脂糖苷的化学成分。对小鼠腹腔注射紫牵牛素6（6）可产生抗抑郁活性。紫牵牛素6（6）、斯卡蒙宁1（8）和斯卡蒙宁2（9）对戊四氮诱导的癫痫发作具有剂量依赖性保护作用。此外，紫牵牛素6（6）和斯卡蒙宁2（9）对离体大鼠回肠的自发收缩有松弛作用。
