马鞍藤（海滩牵牛）的树脂糖苷成分。

Resin glycoside constituents of Ipomoea pes-caprae (beach morning glory).

作者信息

Tao Hongwen, Hao Xiaojiang, Liu Jinggen, Ding Jian, Fang Yuchun, Gu Qianqun, Zhu Weiming

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

出版信息

J Nat Prod. 2008 Dec;71(12):1998-2003. doi: 10.1021/np800386z.

DOI:10.1021/np800386z

PMID:19061389

Abstract

Eight new resin glycosides, pescapreins X-XVII (1-8), were isolated from a lipophilic fraction of an ethanol extract of the entire plant of beach morning glory, Ipomoea pes-caprae. Their structures were elucidated by spectroscopic data analysis and by chemical transformation. These compounds were evaluated biologically in terms of cancer cell line cytotoxicity, antibacterial and antifungal activity, and effects on the mu-opioid receptor.

摘要

从海滩牵牛（Ipomoea pes-caprae）全株乙醇提取物的亲脂性部分中分离出8种新的树脂糖苷，即海滩牵牛素X - XVII（1 - 8）。通过光谱数据分析和化学转化阐明了它们的结构。对这些化合物进行了生物活性评估，包括癌细胞系细胞毒性、抗菌和抗真菌活性以及对μ-阿片受体的影响。