Stinco G, Bragadin G, Trotter D, Pillon B, Patrone P
Institute of Dermatology, Department of Clinical and Experimental Pathology and Medicine, University of Udine, Gemona Hospital, Piazza Rodolone 1, 33013 Gemona del Friuli, Udine, Italy.
J Eur Acad Dermatol Venereol. 2007 Mar;21(3):320-5. doi: 10.1111/j.1468-3083.2006.01914.x.
Acne is a multifactorial disorder in which the sebum plays an important pathogenetic role.
To evaluate the sebostatic effect of three anti-acneic ingredients (azelaic acid, adapalene and benzoyl peroxide) conveyed in cream and to determine whether there is a correlation with the therapeutic results.
Sixty-five patients with mild or moderate acne localized on the face were divided into three therapy groups at random: 25 applied azelaic acid once a day, 20, benzoyl peroxide and 20, adapalene. All the patients were observed at the time of enrolling and a further four times at fortnightly intervals. At each visit the sebum casual level on the forehead, chin and one cheek was measured using a sebumeter. Furthermore, side-effects and clinical-therapeutic effectiveness were noted.
Four patients did not complete the study. Azelaic acid showed an average reduction of 13.9% in sebum production on the forehead, 14.2% on the chin and 15.2% on the cheek. Benzoyl peroxide caused an increase of 10.5% in sebum production on the forehead, 10.3% on the chin and 25.4% on the cheek. Adapalene reduced sebaceous secretion by 0.2% on the forehead and 6.7% on the cheek whereas sebum production increased by 6.2% on the chin. All three drugs showed a clinical improvement in the acneic lesions with moderate adverse effects.
The three topical drugs bring about good therapeutic results with scarce side-effects that do not, however, seem to be correlated with the sebostatic activity.
痤疮是一种多因素疾病，其中皮脂起着重要的致病作用。
评估三种抗痤疮成分（壬二酸、阿达帕林和过氧化苯甲酰）在乳膏中的皮脂抑制作用，并确定其与治疗效果是否存在相关性。
65例面部患有轻度或中度痤疮的患者被随机分为三个治疗组：25例患者每天使用一次壬二酸，20例使用过氧化苯甲酰，20例使用阿达帕林。所有患者在入组时进行观察，并在之后每两周观察一次，共观察四次。每次就诊时，使用皮脂测定仪测量前额、下巴和一侧脸颊的皮脂随机水平。此外，记录副作用和临床治疗效果。
4例患者未完成研究。壬二酸使前额皮脂分泌平均减少13.9%，下巴减少14.2%，脸颊减少15.2%。过氧化苯甲酰使前额皮脂分泌增加10.5%，下巴增加10.3%，脸颊增加25.4%。阿达帕林使前额皮脂分泌减少0.2%，脸颊减少6.7%，而下巴皮脂分泌增加6.2%。所有三种药物在痤疮皮损方面均显示出临床改善，且副作用较轻。
这三种局部用药均带来了良好的治疗效果，副作用较少，但副作用似乎与皮脂抑制活性无关。
Zotero 插件