Endoscopic and histopathological findings in adult dyspeptic patients, and their association with infection in Dhaka, Bangladesh.

OBJECTIVES

Conventional upper-intestinal endoscopy is usually performed to diagnose () associated diseases, using gastric mucosa from the biopsy. The objective of our study was to identify the prevalence of and its relation with endoscopic findings and histopathological features in dyspeptic adult patients.

METHODS

Gastroduodenal biopsy specimens were collected from 143 adult dyspeptic outpatients who attended the Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and Dhaka Medical College Hospital (DMCH), for endoscopy. was identified by rapid urease test (RUT), gene PCR, and histological staining (Giemsa).

RESULTS

The study population was divided into -positive cases (47; 32.9%) and -negative cases (96; 67.1%), based on the case definitions used in the study. The highest rate of infection was found in the 41-50 years age group (25.5%). Endoscopically, 101 (97.1%) dyspeptic patients had gastritis, with the majority of infections found among histopathologically diagnosed duodenal ulcer patients. Endoscopic findings were significantly correlated with histological findings ( < 0.001).

CONCLUSION

Significant correlations between endoscopic and histopathological findings were observed. Early detection and prompt treatment of infection are essential for the prevention of serious complications.