Lee Sun-Young, Park Hyung-Seok, Yu Sang Kyun, Sung In-Kyung, Jin Choon-Jo, Choe Won Hyeok, Kwon So Young, Lee Chang Hong, Choi Kyoo Wan
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea.
Hepatogastroenterology. 2007 Mar;54(74):630-3.
BACKGROUND/AIMS: Detailed information is still lacking on the trends of changes in Helicobacter pylori infection. The aim of the study was to investigate how the prevalence of H. pylori infection varied with gender and age during the past 9 years.
A total of 8646 subjects who submitted to a rapid urease test were included. The prevalence of H. pylori infection according to age and gender was analyzed.
H. pylori infection was noted in 3747 cases (43.3%) of all cases. The infection rate was 50.0% in 1997, but declined gradually down to 40.6% in 2005 (P < 0.001). The rate of H. pylori infection reached a peak at the age of 30-39 years and decreased thereafter in men while it reached a peak at the age of 40-49 years in women (P < 0.001). The prevalence was higher in men than in women before the age 50 years (P < 0.001) while there was no difference after the age 50 years (P = 0.28) in any of the years studied.
H. pylori infection has gradually decreased over the past decade, and there is a gender-related difference in the prevalence of H. pylori infection manifesting as a lower rate of infection in young women and an earlier plateau of infection rate in men.
背景/目的：关于幽门螺杆菌感染变化趋势的详细信息仍然缺乏。本研究的目的是调查在过去9年中幽门螺杆菌感染率如何随性别和年龄变化。
共纳入8646例接受快速尿素酶试验的受试者。分析了幽门螺杆菌感染率与年龄和性别的关系。
所有病例中，3747例（43.3%）检测出幽门螺杆菌感染。1997年感染率为50.0%，但逐渐下降，到2005年降至40.6%（P<0.001）。男性幽门螺杆菌感染率在30 - 39岁达到峰值，之后下降；而女性在40 - 49岁达到峰值（P<0.001）。在50岁之前，男性的感染率高于女性（P<0.001），而在50岁之后，在任何研究年份中两者均无差异（P = 0.28）。
在过去十年中，幽门螺杆菌感染率逐渐下降，并且幽门螺杆菌感染率存在性别差异，表现为年轻女性感染率较低，男性感染率更早达到平台期。
