Rodrigo Juan Pablo, Dominguez Francisco, Suárez Vanessa, Canel Marta, Secades Pablo, Chiara Maria Dolores
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Arch Otolaryngol Head Neck Surg. 2007 Feb;133(2):145-50. doi: 10.1001/archotol.133.2.145.
To explore the value of E-cadherin and focal adhesion kinase (FAK) expression in the prediction of cervical lymph node metastases in squamous cell carcinoma of the supraglottic larynx.
Immunohistochemical analysis of retrospectively selected cases. Patients The study population was composed of 95 previously untreated men with squamous cell carcinoma of the supraglottic larynx. Intervention All the patients underwent surgical resection of the tumor and bilateral neck dissection.
E-cadherin and FAK expression in relation to nodal metastases.
Decreased E-cadherin expression was correlated with the presence of nodal metastases (P = .006). The combination of E-cadherin and FAK expression resulted in a superior accuracy in assessing nodal metastasis (P = .001). Histological grade was also associated with nodal metastases (P = .005). Multivariate analysis confirmed that these parameters were independent predictors of nodal metastases. In addition, the cases with decreased E-cadherin and increased FAK expression presented a significantly reduced disease-specific survival (P = .005).
The combination of the expression of E-cadherin and FAK could increase our ability to identify patients with clinically negative lymph nodes who are at considerable risk for occult metastases.
探讨E-钙黏蛋白和黏着斑激酶（FAK）表达在声门上型喉鳞状细胞癌颈淋巴结转移预测中的价值。
对回顾性选择的病例进行免疫组织化学分析。患者研究人群由95例先前未接受治疗的声门上型喉鳞状细胞癌男性患者组成。干预所有患者均接受肿瘤手术切除及双侧颈清扫术。
E-钙黏蛋白和FAK表达与淋巴结转移的关系。
E-钙黏蛋白表达降低与淋巴结转移的存在相关（P = 0.006）。E-钙黏蛋白和FAK表达的联合检测在评估淋巴结转移方面具有更高的准确性（P = 0.001）。组织学分级也与淋巴结转移相关（P = 0.005）。多变量分析证实这些参数是淋巴结转移的独立预测因素。此外，E-钙黏蛋白表达降低且FAK表达增加的病例疾病特异性生存率显著降低（P = 0.005）。
E-钙黏蛋白和FAK表达的联合检测可提高我们识别临床淋巴结阴性但存在隐匿转移高风险患者的能力。
