Amizadeh Maryam, Dabiri Shahryar, Javedan Armin, Eftekharian Ali, Arabi-Mianroodi Aliasghar
Assistant Professor, Clinical Research Unit, Shafa Hospital, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Professor, Department of Pathology AND Stem Cell Research Center, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Addict Health. 2017 Jan;9(1):11-16.
Metalloproteinase-9 exists in the basement membrane of normal tissues and is a major factor in cancer invasion and lymphatic metastasis. Smoking has been reported to increase the metalloproteinase level, but the role of opium consumption in metalloproteinase level has not yet been examined. The current research intended to examine the impacts of opium consumption on the serum levels of metalloproteinase.
This case-control research was conducted in Kerman (in the southeast of Iran), after getting medical approve by the ethics committee. Case group of 33 non-smokers with no active inflammatory diseases who had the experience of inhaled opium and its derivatives were compared with a control group of 40 non-smokers with no active inflammatory disease and no experience of inhaled opium and its derivatives. Student's t-test, mean, and chi-square test were employed to determine the correlation between the variables.
No statistically meaningful variation was detected in plasma metalloproteinase concentration between the case and control groups (P = 0.160). Also, there was no significant relation between the plasma metalloproteinase concentration and urinary morphine in case groups (P = 0.410), but a statistically significant correlation was found between gender and metalloproteinase in both the case and control groups (P = 0.003).
According to the possible role of opioid drugs in cancer and its prognosis both directly and through their impact on serum levels of metalloproteinase, further studies are suggested.
金属蛋白酶-9存在于正常组织的基底膜中，是癌症侵袭和淋巴转移的主要因素。据报道，吸烟会增加金属蛋白酶水平，但吸食鸦片对金属蛋白酶水平的作用尚未得到研究。目前的研究旨在探讨吸食鸦片对金属蛋白酶血清水平的影响。
本病例对照研究在克尔曼（伊朗东南部）进行，经伦理委员会医学批准。将33名无活动性炎症疾病且有吸食鸦片及其衍生物经历的非吸烟者病例组与40名无活动性炎症疾病且无吸食鸦片及其衍生物经历的非吸烟者对照组进行比较。采用学生t检验、均值和卡方检验来确定变量之间的相关性。
病例组和对照组之间血浆金属蛋白酶浓度未检测到统计学上有意义的差异（P = 0.160）。此外，病例组血浆金属蛋白酶浓度与尿吗啡之间也无显著关系（P = 0.410），但病例组和对照组中性别与金属蛋白酶之间均存在统计学上的显著相关性（P = 0.003）。
鉴于阿片类药物在癌症及其预后中可能直接或通过影响金属蛋白酶血清水平发挥作用，建议进一步研究。
