Bogle Melissa A, Arndt Kenneth A, Dover Jeffrey S
SkinCare Physicians, Chestnut Hill, MA, USA.
Arch Dermatol. 2007 Feb;143(2):168-74. doi: 10.1001/archderm.143.2.168.
To evaluate the use of multiple, low-energy, full-face plasma skin regeneration treatments.
Plasma skin regeneration delivers energy to the skin through plasma pulses induced by passing radiofrequency into nitrogen gas. Single-treatment, high-energy, 1-pass treatments have been demonstrated to achieve good results with an excellent safety profile. Eight volunteers underwent full-face treatments every 3 weeks, for a total of 3 treatments, using energy settings of 1.2 to 1.8 J. Before each subsequent treatment, the quality of regenerated epidermis, the degree of downtime, and erythema were recorded. Full-thickness skin biopsy specimens were obtained from 6 patients before treatment and 90 days following the last treatment. Patients were seen for follow-up 4 days after each treatment and 30 and 90 days after the third treatment.
Three months after treatment, investigators found a 37% reduction in facial rhytids and study participants noted a 68% improvement in overall facial appearance. Reepithelialization was complete in 4 days. Patients assessed erythema to persist an average of 6 days after treatment. Epidermal regeneration from the first treatment was longer than from the following treatments (9 vs 4 and 5 days, respectively). One patient developed localized hyperpigmentation after the first treatment, which resolved by follow-up at day 30. No scarring or hypopigmentation occurred. A histologic evaluation 3 months after treatment revealed a band of new collagen at the dermoepidermal junction with less dense elastin in the upper dermis. The mean depth of new collagen was 72.3 mum.
Plasma skin regeneration using the multiple low-energy treatment technique allows significant successful treatment of photodamaged facial skin with minimal downtime. Results are comparable to a single high-energy treatment, but with less healing time.
评估多次低能量全脸等离子皮肤再生治疗的应用效果。
等离子皮肤再生通过将射频传入氮气产生的等离子脉冲向皮肤输送能量。单次高能量单程治疗已被证明能取得良好效果且安全性极佳。八名志愿者每3周接受一次全脸治疗，共进行3次，能量设置为1.2至1.8焦耳。在每次后续治疗前，记录再生表皮的质量、停工期长短及红斑情况。在治疗前从6名患者身上获取全层皮肤活检标本，并在最后一次治疗后90天再次获取。每次治疗后4天以及第三次治疗后30天和90天对患者进行随访。
治疗三个月后，研究人员发现面部皱纹减少了37%，研究参与者指出整体面部外观改善了68%。4天内上皮再形成完成。患者评估红斑在治疗后平均持续6天。第一次治疗后的表皮再生时间比后续治疗长（分别为9天与4天和5天）。一名患者在第一次治疗后出现局部色素沉着，在第30天随访时消退。未出现瘢痕形成或色素减退。治疗三个月后的组织学评估显示，真皮表皮交界处有一条新胶原带，真皮上层的弹性蛋白密度较低。新胶原的平均深度为72.3微米。
采用多次低能量治疗技术的等离子皮肤再生能够成功显著治疗光损伤面部皮肤，且停工期最短。效果与单次高能量治疗相当，但愈合时间更短。
