APOE ε4与多发性硬化症患者的言语学习受损有关。
APOE epsilon4 is associated with impaired verbal learning in patients with MS.
作者信息
Koutsis G, Panas M, Giogkaraki E, Potagas C, Karadima G, Sfagos C, Vassilopoulos D
机构信息
Department of Neurology, University of Athens, Aeginition Hospital, Greece.
出版信息
Neurology. 2007 Feb 20;68(8):546-9. doi: 10.1212/01.wnl.0000254468.51973.44.
OBJECTIVE
To investigate the effect of APOE epsilon4 on different cognitive domains in a population of Greek patients with multiple sclerosis (MS).
METHODS
A total of 125 patients with MS and 43 controls were included in this study and underwent neuropsychological assessment with Rao's Brief Repeatable Battery. All patients with MS were genotyped for APOE. The effect of APOE epsilon4 on different cognitive domains was investigated.
RESULTS
Fifty-one percent of patients with MS were cognitively impaired. E4 carriers had a sixfold increase in the relative risk of impairment in verbal learning vs noncarriers (OR 6.28, 95% CI 1.74 to 22.69). This effect was domain-specific and was not observed in other cognitive domains assessed by the battery.
CONCLUSION
We found an association of APOE epsilon4 with impaired verbal learning in patients with multiple sclerosis.
目的
研究APOE ε4对希腊多发性硬化症（MS）患者群体中不同认知领域的影响。
方法
本研究共纳入125例MS患者和43名对照，并使用Rao简易重复成套测验进行神经心理学评估。所有MS患者均进行APOE基因分型。研究了APOE ε4对不同认知领域的影响。
结果
51%的MS患者存在认知障碍。与非携带者相比，E4携带者在言语学习方面出现障碍的相对风险增加了6倍（比值比6.28，95%置信区间1.74至22.69）。这种影响具有领域特异性，在该成套测验评估的其他认知领域未观察到。
结论
我们发现APOE ε4与多发性硬化症患者的言语学习障碍有关。
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