Shi Jiong, Tu Jiang-Long, Gale Shawn D, Baxter Leslie, Vollmer Timothy L, Campagnolo Denise I, Tyry Tuula M, Zhuang Yi, Kuniyoshi Sandra M
Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Cogn Behav Neurol. 2011 Sep;24(3):128-33. doi: 10.1097/WNN.0b013e31823380b5.
: In previous studies we and others have demonstrated an association with apolipoprotein (APOE) ε4 genotype and the presence of cognitive deficits in multiple sclerosis (MS). In this follow-up study, we have assessed whether APOE ε4 status exacerbates progression of cognitive deficits in MS.
: A total of 197 patients with MS were assessed for APOE genotype, and baseline cognitive performance was measured using a standardized battery of tests. One hundred seventy patients (86.3%) were clinically followed up for 1 year and were assessed for progression of cognitive deficits.
: The APOE ε4 allele was present in 24.7% of patients. During 1-year follow-up, significant progression of cognitive deficits was found in APOE ε4 carriers (P=0.001) after logistic regression analysis controlling for sex, ethnicity, age, education, disease duration, severity, and subtype.
: APOE ε4 carriers with MS have worsening progression of cognitive deficits than noncarriers. APOE ε4 carrier status predicts cognitive decline in verbal learning and memory.
在之前的研究中，我们及其他研究人员已证实载脂蛋白（APOE）ε4基因型与多发性硬化症（MS）中的认知缺陷存在关联。在这项随访研究中，我们评估了APOE ε4状态是否会加剧MS患者认知缺陷的进展。
共对197例MS患者进行了APOE基因型评估，并使用一套标准化测试来测量其基线认知表现。170例患者（86.3%）接受了为期1年 的临床随访，并对认知缺陷的进展情况进行了评估。
24.7%的患者存在APOE ε4等位基因。在对性别、种族、年龄、教育程度、病程、严重程度和亚型进行逻辑回归分析后，发现在1年的随访期间，APOE ε4携带者的认知缺陷有显著进展（P = 0.001）。
与非携带者相比，携带APOE ε4的MS患者认知缺陷进展更严重。APOE ε4携带者状态可预测言语学习和记忆方面的认知衰退。
