载脂蛋白E基因型与蛛网膜下腔出血后的认知：一项纵向研究。
ApoE genotype and cognition after subarachnoid haemorrhage: a longitudinal study.
作者信息
Louko A-M, Vilkki J, Niskakangas T
机构信息
Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland.
出版信息
Acta Neurol Scand. 2006 Nov;114(5):315-9. doi: 10.1111/j.1600-0404.2006.00676.x.
OBJECTIVES
To investigate the effect of the apolipoprotein epsilon4 allele on cognitive functions after aneurysmal subarachnoid haemorrhage (SAH) in a longitudinal study.
MATERIALS AND METHODS
Performances of 19 patients with and 27 patients without the epsilon4 allele were compared on eight cognitive test variables measured 1-4.5 years and 12-15 years after SAH.
RESULTS
In the baseline examination, epsilon4 patients scored worse than non-epsilon4 patients on verbal fluency (P < 0.05). In the follow-up, a visual memory task and interference in colour naming showed more pronounced impairments from baseline in epsilon4 carriers than in non-carriers.
CONCLUSION
Presence of the epsilon4 allele poses a minor risk for late cognitive impairment after the subacute phase of aneurysmal SAH.
目的
在一项纵向研究中，调查载脂蛋白ε4等位基因对动脉瘤性蛛网膜下腔出血（SAH）后认知功能的影响。
材料与方法
比较19例携带ε4等位基因的患者和27例未携带该等位基因的患者在SAH后1 - 4.5年及12 - 15年所测量的八个认知测试变量上的表现。
结果
在基线检查中，携带ε4等位基因的患者在语言流畅性方面得分低于未携带该等位基因的患者（P < 0.05）。在随访中，与未携带ε4等位基因的患者相比，携带该等位基因的患者在视觉记忆任务和颜色命名干扰方面从基线起的损害更为明显。
结论
ε4等位基因的存在对动脉瘤性SAH亚急性期后的晚期认知障碍构成较小风险。
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