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1例人类免疫缺陷病毒(HIV)感染患者在开始抗逆转录病毒治疗后出现免疫重建综合征的结核病病例

[A case of tuberculosis showing immune reconstitution syndrome after the initiation of antiretroviral therapy for HIV infection].

作者信息

Taniguchi Hirokazu, Izumi Saburo

机构信息

Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78, Nishinagae, Toyama-shi, Toyama 930-8550 Japan.

出版信息

Kekkaku. 2007 Jan;82(1):27-31.

Abstract

Abstract A 27-year-old man admitted for high fever, wet cough and abnormality on his chest radiograph. He was diagnosed as pulmonary tuberculosis, and started treatment with INH, RFP, EB, and PZA. After other examinations, he was diagnosed as having a acquired immunodeficiency syndrome, too. We gave him zidovudine and lamivudine/ abacavir sulfate to treat HIV infection. After starting treatment with anti-tuberculosis drugs his fever alleviated, but after 10 days from the start of anti-HIV drugs, he showed high fever, and abnormality of his chest radiograph exacervated. We diagnosed him as immune reconstitution syndrome, and gave him prednisolone 30 mg/day. His symptoms improved gradually.

摘要

摘要 一名27岁男性因高热、湿性咳嗽及胸部X线片异常入院。他被诊断为肺结核,并开始使用异烟肼、利福平、乙胺丁醇和吡嗪酰胺进行治疗。经过其他检查,他也被诊断为获得性免疫缺陷综合征。我们给予他齐多夫定和拉米夫定/硫酸阿巴卡韦来治疗HIV感染。开始抗结核药物治疗后,他的发热症状有所缓解,但在开始抗HIV药物治疗10天后,他再次出现高热,胸部X线片异常加重。我们将其诊断为免疫重建综合征,并给予他30毫克/天的泼尼松龙。他的症状逐渐改善。

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